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Title: | Using a 31-Gene Expression Profile Test to Stratify Patients with Stage I-II Cutaneous Melanoma According to Recurrence Risk: Update to a Prospective, Multicenter Study |
Author: | Podlipnik, Sebastian Boada, Aram López Estebaranz, José Luis Martín González, Manuel M. Redondo, Pedro Martin, Brian Quick, Ann P. Bailey, Christine N. Kurley, Sarah J. Cook, Robert W. Puig i Sardà, Susana |
Keywords: | Melanoma Medicina personalitzada Melanoma Personalized medicine |
Issue Date: | 19-Feb-2022 |
Publisher: | MDPI AG |
Abstract: | Fifteen to forty percent of patients with localized cutaneous melanoma (CM) (stages I-II) will experience disease relapse. The 31-gene expression profile (31-GEP) uses gene expression data from the primary tumor in conjunction with clinicopathologic features to refine patient prognosis. The study's objective was to evaluate 31-GEP risk stratification for disease-free survival (DFS) in a previously published cohort with longer follow-up.Patients with stage IB-II CM (n = 86) were prospectively tested with the 31-GEP. Follow-up time increased from 2.2 to 3.9 years. Patient outcomes were compared using Kaplan-Meier and Cox regression analysis.A Class 2B result was a significant predictor of 3-year DFS (hazard ratio (HR) 8.4, p = 0.008) in univariate analysis. The 31-GEP significantly stratified patients by risk of relapse (p = 0.005). A Class 2B result was associated with a lower 3-year DFS (75.0%) than a Class 1A result (100%). The 31-GEP had a high sensitivity (77.8%) and negative predictive value (95.0%).The 31-GEP is a significant predictor of disease relapse in patients with stage IB-II melanoma and accurately stratified patients by risk of relapse. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers14041060 |
It is part of: | Cancers, 2022, vol. 14, num. 4 |
URI: | http://hdl.handle.net/2445/209146 |
Related resource: | https://doi.org/10.3390/cancers14041060 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Using a 31-Gene Expression Profile Test to Stratify Patients with Stage I–II Cutaneous Melanoma_Cancers.pdf | 633.51 kB | Adobe PDF | View/Open |
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