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http://hdl.handle.net/2445/209163
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DC Field | Value | Language |
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dc.contributor.author | Hoang, Truong Huu | - |
dc.contributor.author | Sato Matsubara, Misako | - |
dc.contributor.author | Yuasa, Hideto | - |
dc.contributor.author | Matsubara, Tsutomu | - |
dc.contributor.author | Thuy, Le Thi Thanh | - |
dc.contributor.author | Ikenaga, Hiroko | - |
dc.contributor.author | Phuong, Dong Minh | - |
dc.contributor.author | Hanh, Ngo Vinh | - |
dc.contributor.author | Hieu, Vu Ngoc | - |
dc.contributor.author | Hoang, Dinh Viet | - |
dc.contributor.author | Hai, Hoang | - |
dc.contributor.author | Okina, Yoshinori | - |
dc.contributor.author | Enomoto, Masaru | - |
dc.contributor.author | Tamori, Akihiro | - |
dc.contributor.author | Daikoku, Atsuko | - |
dc.contributor.author | Urushima, Hayato | - |
dc.contributor.author | Ikeda, Kazuo | - |
dc.contributor.author | Dat, Ninh Quoc | - |
dc.contributor.author | Yasui, Yutaka | - |
dc.contributor.author | Shinkawa, Hiroji | - |
dc.contributor.author | Kubo, Shoji | - |
dc.contributor.author | Yamagishi, Ryota | - |
dc.contributor.author | Ohtani, Naoko | - |
dc.contributor.author | Yoshizato, Katsutoshi | - |
dc.contributor.author | Gracia Sancho, Jordi | - |
dc.contributor.author | Kawada, Norufumi | - |
dc.date.accessioned | 2024-03-25T13:58:54Z | - |
dc.date.available | 2024-03-25T13:58:54Z | - |
dc.date.issued | 2022-09-30 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209163 | - |
dc.description.abstract | Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by the destruction of fenestrae and appears under pathological conditions; nevertheless, their role in metastasis of cancer cells to the liver remained unexplored. We elucidated that hepatotoxin-damaged and fibrotic livers gave rise to LSECs-iGap formation, which was positively correlated with increased numbers of metastatic liver foci after intrasplenic injection of Hepa1-6 cells. Hepa1-6 cells induced interleukin-23-dependent tumor necrosis factor-α (TNF-α) secretion by LSECs and triggered LSECs-iGap formation, toward which their processes protruded to transmigrate into the liver parenchyma. TNF-α triggered depolymerization of F-actin and induced matrix metalloproteinase 9 (MMP9), intracellular adhesion molecule 1, and CXCL expression in LSECs. Blocking MMP9 activity by doxycycline or an MMP2/9 inhibitor eliminated LSECs-iGap formation and attenuated liver metastasis of Hepa1-6 cells. Overall, this study revealed that cancer cells induced LSEC-iGap formation via proinflammatory paracrine mechanisms and proposed MMP9 as a favorable target for blocking cancer cell metastasis to the liver. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.abo5525 | - |
dc.relation.ispartof | Science Advances, 2022, vol. 8, num. 39 | - |
dc.relation.uri | https://doi.org/10.1126/sciadv.abo5525 | - |
dc.rights | cc by-nc (c) Hoang, Truong Huu et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Càncer de fetge | - |
dc.subject.classification | Endoteli | - |
dc.subject.other | Liver cancer | - |
dc.subject.other | Endothelium | - |
dc.title | Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-07-13T12:43:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9330753 | - |
dc.identifier.pmid | 36170363 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Cancer cells produce liver metastasis via gap formation in sinusoidal_ScienceAdvances.pdf | 8.43 MB | Adobe PDF | View/Open |
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