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DC Field | Value | Language |
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dc.contributor.author | Morote, Juan | - |
dc.contributor.author | Picola, Natàlia | - |
dc.contributor.author | Muñoz Rodríguez, Jesús | - |
dc.contributor.author | Paesano, Nahuel | - |
dc.contributor.author | Ruiz Plazas, Xavier | - |
dc.contributor.author | Muñoz Rivero, Marta V. | - |
dc.contributor.author | Celma, Anna | - |
dc.contributor.author | García de Manuel, Gemma | - |
dc.contributor.author | Aisian, Ignacio | - |
dc.contributor.author | Servian, Pol | - |
dc.contributor.author | Abascal, José M. | - |
dc.date.accessioned | 2024-03-26T19:49:03Z | - |
dc.date.available | 2024-03-26T19:49:03Z | - |
dc.date.issued | 2023-09-13 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209248 | - |
dc.description.abstract | The primary objective of this study was to analyse the current accuracy of targeted and systematic prostate biopsies in detecting csPCa. A secondary objective was to determine whether there are factors predicting the finding of csPCa in targeted biopsies and, if so, to explore the utility of a predictive model for csPCa detection only in targeted biopsies. We analysed 2122 men with suspected PCa, serum PSA > 3 ng/mL, and/or a suspicious digital rectal examination (DRE), who underwent targeted and systematic biopsies between 2021 and 2022. CsPCa (grade group 2 or higher) was detected in 1026 men (48.4%). Discrepancies in csPCa detection in targeted and systematic biopsies were observed in 49.6%, with 13.9% of csPCa cases being detected only in systematic biopsies and 35.7% only in targeted biopsies. A predictive model for csPCa detection only in targeted biopsies was developed from the independent predictors age (years), prostate volume (mL), PI-RADS score (3 to 5), mpMRI Tesla (1.5 vs. 3.0), TRUS-MRI fusion image technique (cognitive vs. software), and prostate biopsy route (transrectal vs. transperineal). The csPCa discrimination ability of targeted biopsies showed an AUC of 0.741 (95% CI 0.721-0.762). The avoidance rate of systematic prostate biopsies went from 0.5% without missing csPCa to 18.3% missing 4.6% of csPCa cases. We conclude that the csPCa diagnostic accuracy of targeted biopsies is higher than that of systematic biopsies. However, a significant rate of csPCa remains detected only in systematic biopsies. A predictive model for the partial omission of systematic biopsies was developed. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers15184543 | - |
dc.relation.ispartof | Cancers, 2023, vol. 15, num. 18 | - |
dc.relation.uri | https://doi.org/10.3390/cancers15184543 | - |
dc.rights | cc by (c) Morote, Juan et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Biòpsia | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Biopsy | - |
dc.title | A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-10-25T10:27:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37760511 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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cancers-15-04543.pdf | 597.47 kB | Adobe PDF | View/Open |
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