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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/209323
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dc.contributor.authorWhelan, Rory-
dc.contributor.authorMayor Ruiz, Cristina-
dc.date.accessioned2024-04-02T09:28:40Z-
dc.date.issued2024-02-16-
dc.identifier.issn1545-9985-
dc.identifier.urihttp://hdl.handle.net/2445/209323-
dc.description.abstractUbiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.ca
dc.format.extent3 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41594-024-01215-8-
dc.relation.ispartofNature Structural & Molecular Biology, 2024, vol. 31, p. 205-207-
dc.relation.urihttps://doi.org/10.1038/s41594-024-01215-8-
dc.rights(c) Springer Nature, 2024-
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))-
dc.subject.classificationDisseny de medicaments-
dc.subject.classificationModificació química de les proteïnes-
dc.subject.otherDrug design-
dc.subject.otherChemical modification of proteins-
dc.titleChemical rewiring of ubiquitination by degraders and their selectivity routesca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.date.updated2024-03-27T12:07:38Z-
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccessca
dc.embargo.lift2024-08-16-
dc.date.embargoEndDateinfo:eu-repo/date/embargoEnd/2024-08-16ca
dc.identifier.idimarina6608424-
dc.identifier.pmid38366231-
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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