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Title: | Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios |
Author: | Galvan Femenia, Ivan Díez Villanueva, Anna Martín, Berta Moratalla Navarro, Ferran Morón-Duran, Francisco D Obón Santacana, Mireia Carreras, Anna Cid, Rafael de Peinado Morales, Miguel Á. (Miguel Ángel) Moreno Aguado, Víctor |
Keywords: | Epigènesi ADN Genoma humà Epigenesis DNA Human genome |
Issue Date: | 2-Dec-2023 |
Publisher: | Nature Publishing Group |
Abstract: | Genome-wide association studies have identified thousands of loci associated with common diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic modifications, such as the observed in DNA methylation have been proposed as a mechanism of intergenerational inheritance. To investigate the potential contribution of DNA methylation to the missing heritability, we analysed the methylomes of four healthy trios (two parents and one offspring) using whole genome bisulphite sequencing. Of the 1.5 million CpGs (19%) with over 20% variability between parents in at least one family and compatible with a Mendelian inheritance pattern, only 3488 CpGs (0.2%) lacked correlation with any SNP in the genome, marking them as potential sites for intergenerational epigenetic inheritance. These markers were distributed genome-wide, with some preference to be located in promoters. They displayed a bimodal distribution, being either fully methylated or unmethylated, and were often found at the boundaries of genomic regions with high/low GC content. This analysis provides a starting point for future investigations into the missing heritability of simple and complex traits. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-023-48517-3 |
It is part of: | Scientific Reports, 2023, vol. 13, num.1 |
URI: | http://hdl.handle.net/2445/209345 |
Related resource: | https://doi.org/10.1038/s41598-023-48517-3 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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