Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Abstract

<p>Photoallergy, a unique form of skin sensitization induced by specific compounds under</p><p>ultraviolet irradiation, has traditionally been investigated using animals. However, the prohibition of</p><p>animal testing for the assessment of cosmetic ingredients in Europe and other countries underscores</p><p>the necessity for in vitro or in silico alternative methods. Currently, there are no validated methods for</p><p>assessing photoallergy or photosensitization, presenting a significant challenge in the development of</p><p>new cosmetic ingredients. This review examines the landscape of alternative methods for detecting</p><p>photosensitization, emphasizing recent publications, and considering the underlying principles of</p><p>the different proposed assays.</p>