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Title: | [RuCl2(η6 ‑p‑cymene)(P*)] and [RuCl2(κ-P*‑η6 ‑arene)] Complexes Containing P‑Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA |
Author: | Aznar García, Rosario Grabulosa, Arnald Mannu, Alberto Müller Jevenois, Guillermo Sainz García, Daniel Moreno Aguado, Víctor Font Bardia, Ma. Mercedes Calvet Pallàs, Maria Teresa Lorenzo, Julia |
Keywords: | Lligands Compostos organometàl·lics Estructura cristal·lina (Sòlids) Ruteni Ligands Organometallic compounds Layer structure (Solids) Ruthenium |
Issue Date: | 2013 |
Publisher: | American Chemical Society |
Abstract: | The preparation of a series of half-sandwich ruthenium complexes, [RuCl2(η6-p-cymene)(P*)] (P* = SPMeRR′) and [RuCl2(κ-P*-η6-arene)], containing P-stereogenic phosphines is reported. The borane-protected Pstereogenic phosphines have been obtained by addition of the (H3B)PMe2R (R = t-Bu (1), Cy (2), Fc (3))/sec-BuLi/ (−)-sparteine adduct to benzyl halides, carbonyl functions, and epoxides with yields between 40 and 90% and ee values in the 70−99% range. Those containing an aryl secondary function have been used in the preparation of [RuCl2(η6 -p-cymene)-(P*)] complexes. Borane deprotection has been performed using HBF4, except for (H3B)PRMe(CH2SiMe2Ph) phosphines, where DABCO was used to avoid partial cleavage of the CH2− Si bond. In the case of (H3B)P(t-Bu)Me(CH2C(OH)Ph2) (1l) the dehydrated phosphine was obtained. The tethered complexes were obtained by p-cymene substitution in chlorobenzene at 120 °C, except for ferrocenyl-containing complexes, which decomposed upon heating. The presence of substituents in the aryl arm of some of the phosphines introduces new chiral elements in the tethered [RuCl2(κ-P*-η6-arene)] compounds. Full characterization of all compounds both in solution and in the solid state has been carried out. Crystal structure determinations of four phosphine−borane molecules confirm the S configuration at the phosphorus atom (1a,e,l and 2d). Moreover, the crystal structure of one p-cymene complex (5i) and four tethered complexes reveal the strain of the compounds with two atoms in the tether (7c,g,l and 8i). Tethering has a marked effect on the catalytic performance transfer hydrogenation of acetophenone and on the nature of hydridic species originating during the activation period. The chiral induction attains 58% ee with complexes with the bulkiest substituents in the pendant arm of the phosphine. Three of the prepared complexes can interact with DNA and present a reasonable cytotoxicity toward cancer cells. Intercalation of the free aromatic pendant arm of the phosphines seems to be fundamental for such interactions. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/om3012294 |
It is part of: | Organometallics, 2013, vol. 32, num.8, p. 2344-2362 |
URI: | http://hdl.handle.net/2445/209421 |
Related resource: | https://doi.org/10.1021/om3012294 |
ISSN: | 0276-7333 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) Articles publicats en revistes (Ciències Clíniques) |
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