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http://hdl.handle.net/2445/209505
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DC Field | Value | Language |
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dc.contributor.author | Melé Casas, Maria | - |
dc.contributor.author | Launes Montaña, Cristian | - |
dc.contributor.author | Fernández de Sevilla Estrach, Mariona | - |
dc.contributor.author | Hernández García, María | - |
dc.contributor.author | Pons Tomàs, Gemma | - |
dc.contributor.author | Bassat Orellana, Quique | - |
dc.contributor.author | Fumadó, Victoria | - |
dc.contributor.author | Fortuny Guasch, Claudia | - |
dc.contributor.author | Garcia Miquel, Aleix | - |
dc.contributor.author | Bonet Carné, Elisenda | - |
dc.contributor.author | Prats, Clara | - |
dc.contributor.author | Ajanovic, Sara | - |
dc.contributor.author | Cubells, Marta | - |
dc.contributor.author | Claverol, Joana | - |
dc.contributor.author | Penela Sánchez, Daniel | - |
dc.contributor.author | Jou, Cristina | - |
dc.contributor.author | Arias, Sara | - |
dc.contributor.author | Balanza, Núria | - |
dc.contributor.author | Baro, Bàrbara | - |
dc.contributor.author | Millat-Martínez, Pere | - |
dc.contributor.author | Alonso Muñoz, Sergio | - |
dc.contributor.author | Álvarez Lacalle, Enrique | - |
dc.contributor.author | Català, Martí | - |
dc.contributor.author | Cuadras, Daniel | - |
dc.contributor.author | Muñoz-Almagro, Carmen | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.contributor.author | Jordán García, Iolanda | - |
dc.contributor.author | García García, Juan José | - |
dc.date.accessioned | 2024-04-08T15:46:52Z | - |
dc.date.available | 2024-04-08T15:46:52Z | - |
dc.date.issued | 2022-11-17 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209505 | - |
dc.description.abstract | Background: Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households. Methods: A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated. Results: 1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01). Conclusions: Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0277754 | - |
dc.relation.ispartof | PLoS One, 2022, vol. 17, num.11 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0277754 | - |
dc.rights | cc-by (c) Mele-Casas, M. et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Infeccions | - |
dc.subject.classification | Família | - |
dc.subject.classification | Infants | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Virus | - |
dc.subject.other | Infections | - |
dc.subject.other | Family | - |
dc.subject.other | Children | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Viruses | - |
dc.title | Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 728244 | - |
dc.date.updated | 2024-04-08T15:46:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9332626 | - |
dc.identifier.pmid | 36395194 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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255265.pdf | 1.3 MB | Adobe PDF | View/Open |
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