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DC Field | Value | Language |
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dc.contributor.author | Ronda, Mar | - |
dc.contributor.author | Gumucio Sanguino, Víctor D. | - |
dc.contributor.author | Shaw, Evelyn | - |
dc.contributor.author | Granada, Rosa | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Santafosta, Eva | - |
dc.contributor.author | Sabater, Joan | - |
dc.contributor.author | Esteve, Francisco | - |
dc.contributor.author | Tebé, Cristian | - |
dc.contributor.author | Mañez, Rafael | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | Puig Asensio, Mireia | - |
dc.contributor.author | Cobo Sacristán, Sara | - |
dc.contributor.author | Padullés, Ariadna | - |
dc.date.accessioned | 2024-04-09T15:07:52Z | - |
dc.date.available | 2024-04-09T15:07:52Z | - |
dc.date.issued | 2024-01-29 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209565 | - |
dc.description.abstract | Information on the long-term effects of non-restrictive antimicrobial stewardship (AMS) strategies is scarce. We assessed the effect of a stepwise, multimodal, non-restrictive AMS programme on broad-spectrum antibiotic use in the intensive care unit (ICU) over an 8-year period. Components of the AMS were progressively implemented. Appropriateness of antibiotic prescribing was also assessed by monthly point-prevalence surveys from 2013 onwards. A Poisson regression model was fitted to evaluate trends in the reduction of antibiotic use and in the appropriateness of their prescription. From 2011 to 2019, a total of 12,466 patients were admitted to the ICU. Antibiotic use fell from 185.4 to 141.9 DDD per 100 PD [absolute difference, -43.5 (23%), 95% CI -100.73 to 13.73; p = 0.13] and broad-spectrum antibiotic fell from 41.2 to 36.5 [absolute difference, -4.7 (11%), 95% CI -19.58 to 10.18; p = 0.5]. Appropriateness of antibiotic prescribing rose by 11% per year [IRR: 0.89, 95% CI 0.80 to 1.00; p = 0.048], while broad-spectrum antibiotic use showed a dual trend, rising by 22% until 2015 and then falling by 10% per year since 2016 [IRR: 0.90, 95% CI 0.81 to 0.99; p = 0.03]. This stepwise, multimodal, non-restrictive AMS achieved a sustained reduction in broad-spectrum antibiotic use in the ICU and significantly improved appropriateness of antibiotic prescribing. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/antibiotics13020132 | - |
dc.relation.ispartof | Antibiotics, 2024, vol. 13, num. 2 | - |
dc.relation.uri | https://doi.org/10.3390/antibiotics13020132 | - |
dc.rights | cc by (c) Ronda, Mar et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Unitats de cures intensives | - |
dc.subject.classification | Administració de medicaments | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Intensive care units | - |
dc.subject.other | Administration of drugs | - |
dc.title | Long-Term Effects of a Stepwise, Multimodal, Non-Restrictive Antimicrobial Stewardship Programme for Reducing Broad-Spectrum Antibiotic Use in the ICU | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-04-04T07:59:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38391518 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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antibiotics-13-00132-v2.pdf | 2.43 MB | Adobe PDF | View/Open |
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