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http://hdl.handle.net/2445/209723
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DC Field | Value | Language |
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dc.contributor.author | Morote, Juan | - |
dc.contributor.author | Picola, Natàlia | - |
dc.contributor.author | Muñoz Rodríguez, Jesús | - |
dc.contributor.author | Paesano, Nahuel | - |
dc.contributor.author | Ruiz Plazas, Xavier | - |
dc.contributor.author | Muñoz Rivero, Marta V. | - |
dc.contributor.author | Celma, Ana | - |
dc.contributor.author | García de Manuel, Gemma | - |
dc.contributor.author | Miró, Berta | - |
dc.contributor.author | Servian, Pol | - |
dc.contributor.author | Abascal, José M. | - |
dc.date.accessioned | 2024-04-11T09:33:06Z | - |
dc.date.available | 2024-04-11T09:33:06Z | - |
dc.date.issued | 2024-02-05 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | http://hdl.handle.net/2445/209723 | - |
dc.description.abstract | Concerns exist regarding the effects of 5-alpha reductase inhibitors (5-ARIs) on multipa-rametric magnetic resonance imaging (mpMRI) and clinically significant prostate cancer (csPCa) detection. Our objective is to analyze the effect of 5-ARI on the prostate imaging-reporting and data system (PI-RADS) distribution and csPCa and insignificant PCa (iPCa) detection. Among 2212 men with serum prostate-specific antigen levels of >3.0 ng/mL and/or suspicious digital rectal examinations who underwent mpMRI and targeted and/or systematic biopsies, 120 individuals exposed to 5-ARI treatment for over a year were identified. CsPCa was defined when the grade group (GG) was >2. The overall csPCa and iPCa detection rates were 44.6% and 18.8%, respectively. Since logistic regression revealed independent predictors of PCa, a randomized matched group of 236 individuals was selected for analysis. The PI-RADS distribution was comparable with 5-ARI exposure (p 0.685). The CsPCa detection rates in 5-ARI-naive men and 5-ARI-exposed men were 52.6% and 47.4%, respectively (p 0.596). IPCa was detected in 37.6 and 62.5%, respectively (p 0.089). The tumor GG distribution based on 5-ARI exposure was similar (p 0.149) to the rates of csPCa and iPCa across the PI-RADS categories. We conclude that exposure to 5-ARI in suspected PCa men did not change the PI-RADS distribution and the csPCa and iPCa detection rates. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/biom14020193 | - |
dc.relation.ispartof | Biomolecules, 2024, vol. 14, num. 2 | - |
dc.relation.uri | https://doi.org/10.3390/biom14020193 | - |
dc.rights | cc by (c) Morote, Juan et al, 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Diagnosis | - |
dc.title | Effect of 5-Alpha Reductase Inhibitors on Magnetic Resonance Imaging and Prostate Cancer Detection | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-04-04T08:15:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38397430 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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biomolecules-14-00193.pdf | 439.95 kB | Adobe PDF | View/Open |
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