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DC Field | Value | Language |
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dc.contributor.author | Cayuela, Nuria | - |
dc.contributor.author | Domínguez Lizarbe, Manuel | - |
dc.contributor.author | Plans, Gerard | - |
dc.contributor.author | Alemany, Montserrat | - |
dc.contributor.author | Sánchez, Juan José | - |
dc.contributor.author | Andrés, Begoña | - |
dc.contributor.author | Lucas, Anna | - |
dc.contributor.author | Bruna, Jordi | - |
dc.contributor.author | Simó, Marta | - |
dc.date.accessioned | 2024-04-11T09:50:10Z | - |
dc.date.available | 2024-04-11T09:50:10Z | - |
dc.date.issued | 2023-03-24 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209741 | - |
dc.description.abstract | Simple Summary: Up to 50-90% of long-term cancer survivors will exhibit moderate to severe cognitive impairment following cranial radiotherapy (RT). It is common in this population to observe a ventricular dilatation disproportionate to the cerebral atrophy, which clinically manifests similar to normal pressure hydrocephalus (NPH). Previous studies demonstrated that early placement of a ventriculoperitoneal shunt (VPS) may be beneficial. Our study aimed to describe the cognitive, neuroimaging-MRI (cerebrospinal fluid-CSF volumetric analysis), and lumbar infusion test features of a cohort of cancer survivors (n = 36) with suspected post-RT NPH and identify which patients may benefit from a VPS. It was revealed that up to 81% of our cohort met the criteria for cognitive impairment. Additionally, we observed that the addition of a CSF volumetric analysis improved the identification of VPS responders (accuracy of 93%), thus enhancing the management and prognosis of long-term cancer survivors. Background: We examined cognitive, brain MRI, and lumbar infusion test (LIT) features to identify predictors of response to ventriculoperitoneal shunting (VPS) in long-term cancer survivors with suspected normal pressure hydrocephalus (NPH) following cranial radiotherapy (RT). Methods: Patients who completed cranial RT at least 2 years before with clinically suspected NPH and an Evans' index (EI) >= 0.30 underwent a cognitive and a cerebrospinal fluid (CSF) volumetric (MRI) analysis (n = 36). For those in whom VPS was placed (n = 14), we explored whether adding a CSF volumetric analysis to classical MRI and LIT (Tap Test) features would better identify VPS responders. Results: Nearly 80% exhibited cognitive impairment. The CSF volume at NPH diagnoses was significantly larger in the group of VPS responders (p = 0.04). The addition of CSF volume to NPH diagnoses increased accuracy to 93%, with a positive and negative predictive value of 91% and 100%, respectively. Conclusion: The addition of a quantitative MRI analysis of CSF volume to classical MRI and LIT NPH criteria, along with a high clinical suspicion of NPH, may help to identify VPS responders, thus improving the clinical management and prognosis of long-term survivors. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers15071949 | - |
dc.relation.ispartof | Cancers, 2023, vol. 15, num. 7 | - |
dc.relation.uri | https://doi.org/10.3390/cancers15071949 | - |
dc.rights | cc by (c) Cayuela, Nuria et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Radioteràpia | - |
dc.subject.classification | Trastorns de la cognició | - |
dc.subject.other | Radiotherapy | - |
dc.subject.other | Cognition disorders | - |
dc.title | Normal Pressure Hydrocephalus Following Cranial Radiation: Identification of Shunting Responders | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-04-03T08:52:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37046610 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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cancers-15-01949.pdf | 2.07 MB | Adobe PDF | View/Open |
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