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http://hdl.handle.net/2445/209903
Title: | Thrombolysis in Patients With Large‐Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population‐Based Study |
Author: | García Tornel, Álvaro Lozano, Prudencio Rubiera, Marta Requena, Manuel Olivé Gadea, Marta Muchada, Marian Juega, Jesus Rizzo, Federica Rodríguez Villatoro, Noelia Pagola, Jorge Rodríguez Luna, David Boned, Sandra Dorado, Laura Jiménez, Xavier Soto, Angels Cardona, Pere Urra, Xabier Chamorro, Angel Purroy, Francesc Terceño, Mikel Silva, Yolanda Flores, Alan Ustrell, Xavier Zaragoza, Josep Roquer, Jaume Kuprinski, Jerzy Cocho, Dolores Palomeras, Ernest Gómez Choco, Manuel Canovas, David Martí Fábregas, Joan Mas, Natalia Abilleira, Sonia Molina, Carlos Ribó, Marc Pérez de la Ossa, Natalia |
Keywords: | Trombosi Assistència hospitalària Thrombosis Hospital care |
Issue Date: | 1-Sep-2023 |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Abstract: | BACKGROUND: Our goal is to evaluate whether the administration of thrombolytic treatment has varying effects on clinical and radiological outcomes in patients with large-vessel occlusion stroke, based on the type of stroke center where the treatment was given (thrombectomy-capable center versus local stroke center). METHODS: We included patients with an acute ischemic large-vessel occlusion stroke who were directly admitted to thrombectomy-capable centers and treated with endovascular thrombectomy, or were transferred from local stroke centers as thrombectomy candidates, in Catalonia, Spain, between 2017 and 2021. The primary outcome was the shift analysis on the modified Rankin scale score at 90 days. Secondary outcomes included death at 90 days and the rate of parenchymal hemorrhage and successful reperfusion. Inverse-probability weighting clustered at the type of stroke center was used to estimate the effects. RESULTS: The analysis included 2268 patients directly admitted to thrombectomy-capable centers, of whom 975 (49%) were treated with thrombolysis, and 938 patients transferred from local stroke centers, of whom 580 (66%) were treated with thrombolysis and 616 (67%) were treated with thrombectomy. Mean age was 72 (SD +/- 13) years, median National Institute of Health Stroke Scale score was 17 (interquartile range, 12-21), and 1363 patients were women (48%). Patients treated with intravenous thrombolysis were younger, had shorter time from onset to first image, higher Alberta Stroke Program Early Computed Tomography Score, and lower rates of wake-up stroke, atrial fibrillation, and anticoagulation intake. Patients treated with thrombolysis had better functional outcome at 90 days, with no difference between patients directly admitted to thrombectomy-capable centers (adjusted common odds ratio [acOR], 1.50 [95% CI, 1.24-1.81]) and patients transferred from local stroke centers (acOR, 1.44 [95% CI, 1.04-2.01]). Patients treated with intravenous thrombolysis had lower death rate, higher rate of parenchymal hematoma, and similar rate of successful reperfusion, with no difference according to type of center (Pinteraction>0.1). CONCLUSION: Administration of intravenous thrombolysis in patients with a large-vessel stroke with intention of thrombectomy was associated with lower degrees of disability, lower death rate, and higher rates of parenchymal hematoma both in thrombectomycapable centers and in local stroke centers. |
Note: | Reproducció del document publicat a: https://doi.org/10.1161/SVIN.122.000760 |
It is part of: | Stroke: Vascular and Interventional Neurology, 2023, vol. 3, num. 5 |
URI: | http://hdl.handle.net/2445/209903 |
Related resource: | https://doi.org/10.1161/SVIN.122.000760 |
ISSN: | 2694-5746 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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