Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/210362
Title: | Misfolded α-Synuclein in Autosomal Dominant Alzheimer's Disease. |
Author: | Fort Aznar, Laura Molina Porcel, Laura Ramos Campoy, Oscar Esteller Gauxax, Diana Naranjo, Laura Lladó Plarrumaní, Albert Balasa, Mircea Ruiz García, Raquel Antonell, Anna Sánchez del Valle Díaz, Raquel |
Keywords: | Malaltia d'Alzheimer Proteïnes Alzheimer's disease Proteins |
Issue Date: | 12-Jan-2024 |
Publisher: | IOS Press |
Abstract: | We analyzed Lewy body (LB) pathology in 18 autosomal dominant Alzheimer's disease (ADAD) brains via immunohistochemistry. Real-time quaking induced conversion was used to detect misfolded α-synuclein (α-syn) in 18 living ADAD cerebrospinal fluid (CSF) samples. Concomitant LB pathology was present in 44% ADAD brains. Only 6% CSF samples were positive for misfolded α-syn. In an additional AD sample, all patients with confirmed LB presented misfolded α-syn in postmortem CSF regardless of the LB staging. In conclusion, misfolded α-syn in CSF was scarce in symptomatic living ADAD individuals, in contrast to postmortem brain tissue. These results suggest late appearance of LB pathology in ADAD. |
Note: | Preprint del document publicat a: https://doi.org/10.3233/JAD-230919 |
It is part of: | Journal of Alzheimers Disease, 2024 |
URI: | http://hdl.handle.net/2445/210362 |
Related resource: | https://doi.org/10.3233/JAD-230919 |
ISSN: | 1387-2877 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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JAD-230919_R1.pdf | 1.56 MB | Adobe PDF | View/Open |
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