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http://hdl.handle.net/2445/211324
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DC Field | Value | Language |
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dc.contributor.author | Pérez Jurado, Luis A. | - |
dc.contributor.author | Cáceres, Alejandro | - |
dc.contributor.author | Balagué Dobón, Laura | - |
dc.contributor.author | Esko, Tonu | - |
dc.contributor.author | López de Heredia, Miguel | - |
dc.contributor.author | Quintela, Inés | - |
dc.contributor.author | Cruz, Raquel | - |
dc.contributor.author | Lapunzina, Pablo | - |
dc.contributor.author | Carracedo, Ángel | - |
dc.contributor.author | SCOURGE Cohort Group | - |
dc.contributor.author | González, Juan R. | - |
dc.date.accessioned | 2024-05-15T09:19:24Z | - |
dc.date.available | 2024-05-15T09:19:24Z | - |
dc.date.issued | 2024-02-19 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.uri | http://hdl.handle.net/2445/211324 | - |
dc.description.abstract | The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s42003-024-05805-6 | - |
dc.relation.ispartof | Communications Biology, 2024, vol. 7, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s42003-024-05805-6 | - |
dc.rights | cc by (c) Pérez Jurado, Luis A. et al, 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Anomalies cromosòmiques | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Chromosome abnormalities | - |
dc.title | Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-05-08T11:52:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38374351 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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s42003-024-05805-6.pdf | 3.91 MB | Adobe PDF | View/Open |
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