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Title: | Gene-specific ACMG/AMP classification criteria for germline APC variants: Recommendations from the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel |
Author: | Spier, Isabel Yin, Xiaoyu Richardson, Marcy Pineda, Marta Laner, Andreas Ritter, Deborah Boyle, Julie Mur, Pilar Hansen, Thomas V O. Shi, Xuemei Mahmood, Khalid Plazzer, John-paul Ognedal, Elisabet Nordling, Margareta Farrington, Susan M. Yamamoto, Gou Baert-Desurmont, Stéphanie Martins, Alexandra Borras, Ester Tops, Carli Webb, Erica Beshay, Victoria Genuardi, Maurizio Pesaran, Tina Capellá, Gabriel Tavtigian, Sean V. Latchford, Andrew Frayling, Ian M. Plon, Sharon E. Greenblatt, Marc Macrae, Finlay A. Aretz, Stefan |
Issue Date: | 1-Feb-2024 |
Publisher: | Elsevier BV |
Abstract: | Purpose: The Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) was established by the International Society for Gastrointestinal Hereditary Tumours and the Clinical Genome Resource, who set out to develop recommendations for the interpretation of germline APC variants underlying Familial Adenomatous Polyposis, the most frequent hereditary polyposis syndrome. Methods: Through a rigorous process of database analysis, literature review, and expert elicitation, the APC VCEP derived gene -specific modifications to the ACMG/AMP (American College of Medical Genetics and Genomics and Association for Molecular Pathology) variant classification guidelines and validated such criteria through the pilot classification of 58 variants. Results: The APC-specific criteria represented gene- and disease -informed specifications, including a quantitative approach to allele frequency thresholds, a stepwise decision tool for truncating variants, and semiquantitative evaluations of experimental and clinical data. Using the APC-specific criteria, 47% (27/58) of pilot variants were reclassified including 14 previous variants of uncertain significance (VUS). Conclusion: The APC-specific ACMG/AMP criteria preserved the classification of wellcharacterized variants on ClinVar while substantially reducing the number of VUS by 56% (14/25). Moving forward, the APC VCEP will continue to interpret prioritized lists of VUS, the results of which will represent the most authoritative variant classification for widespread clinical use. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.gim.2023.100992 |
It is part of: | Genetics in Medicine, 2024, vol. 26, issue. 2, p. 100992 |
URI: | http://hdl.handle.net/2445/212250 |
Related resource: | https://doi.org/10.1016/j.gim.2023.100992 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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PIIS1098360023010080.pdf | 1.39 MB | Adobe PDF | View/Open |
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