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http://hdl.handle.net/2445/212445
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DC Field | Value | Language |
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dc.contributor.author | Szabo, Dóra | - |
dc.contributor.author | Vasilakopoulou, Alexandra | - |
dc.contributor.author | Naas, Thierry | - |
dc.contributor.author | Gonzalez, Camille | - |
dc.contributor.author | Vila Grajales, Joaquim | - |
dc.contributor.author | Riccobono, Eleonora | - |
dc.contributor.author | Kamotsay, Katalin | - |
dc.contributor.author | Reissier, Sophie | - |
dc.contributor.author | Berbel, Dàmaris | - |
dc.contributor.author | Aszalos, Albert Zoltan | - |
dc.contributor.author | Rosenmoller, Magda | - |
dc.contributor.author | Stankov-Puges, Milovan | - |
dc.contributor.author | Georgiou, Panagiota Christina | - |
dc.contributor.author | Vourli, Sophia | - |
dc.contributor.author | Volland, Hervé | - |
dc.contributor.author | Pournaras, Spyros | - |
dc.date.accessioned | 2024-06-04T17:29:45Z | - |
dc.date.available | 2024-06-04T17:29:45Z | - |
dc.date.issued | 2024-03-07 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | http://hdl.handle.net/2445/212445 | - |
dc.description.abstract | Objectives: A multicentre study evaluating NG-Test DetecTool OXA-23 for the detection of OXA-23 carbapenemase directly from positive blood cultures (PBCs). Methods: The NG-Test DetecTool OXA-23 is an immunoassay that integrates a sample preparation device. We evaluated NG-Test DetecTool OXA-23 on 189 spiked and 126 clinical PBCs. The clinical samples' standard-of-care procedure consisted of bacterial identification from the first day of positivity by MALDI-TOF MS, conventional culture and antimicrobial susceptibility testing. The immunoassay results were verified molecularly. The strains used for the spiked samples consisted of well-characterized Acinetobacter baumannii and Proteus mirabilis strains. Results: The NG-Test DetecTool OXA-23 was evaluated on 315 PBCs and revealed sensitivity of 100% (95% CI: 98.21%-100.00%) and specificity of 100% (95% CI: 96.73%-100.00%). It provided 204 true-positive results for OXA-23 in 196 bottles with carbapenem-resistant A. baumannii (CRAB) and 8 bottles with carbapenem-resistant P. mirabilis and also provided 111 true-negative results. There were no false-positive and no false-negative results. Among the 315 PBCs studied, 83 clinical blood cultures collected in the ICU of a Greek university hospital, which were tested prospectively, all yielded CRAB, and OXA-23 was correctly detected in all samples from the first day of positivity using the NG-Test DetecTool OXA-23. Conclusions: The NG-Test DetecTool OXA-23 has exhibited excellent sensitivity and specificity for OXA-23 detection in PBCs and can provide valuable information for appropriate selection of antibiotic therapy and early implementation of infection control measures. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/jacamr/dlae029 | - |
dc.relation.ispartof | Journal of Antimicrobial Chemotherapy, 2024, vol. 6, num.2 | - |
dc.relation.uri | https://doi.org/10.1093/jacamr/dlae029 | - |
dc.rights | cc-by (c) Szabo, Dóra et al., 2024 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Immunoassaig | - |
dc.subject.classification | Bacteris | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Immunoassay | - |
dc.subject.other | Bacteria | - |
dc.subject.other | Antibiotics | - |
dc.title | A multicentre evaluation of the NG-test DetecTool OXA-23 for the rapid detection of OXA-23 carbapenemase directly from blood cultures | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 748340 | - |
dc.date.updated | 2024-06-04T17:29:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38455379 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Fonaments Clínics) |
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