Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/212564
Title: | Aneuploidy-induced cellular behaviors Insights from Drosophila |
Author: | Joy, Jery Fusari, Elena Milán Kalbfleisch, Marco |
Keywords: | Biochemistry, genetics and molecular biology (all) Biochemistry, genetics and molecular biology (miscellaneous) Biotecnología Cell biology Ciência da computação Ciências biológicas i Ciências biológicas ii Developmental biology General biochemistry,genetics and molecular biology General medicine Molecular biology |
Issue Date: | 5-Feb-2024 |
Publisher: | Elsevier |
Abstract: | A balanced gene complement is crucial for proper cell function. Aneuploidy, the condition of having an imbalanced chromosome set, alters the stoichiometry of gene copy numbers and protein complexes and has dramatic consequences at the cellular and organismal levels. In humans, aneuploidy is associated with different pathological conditions including cancer, microcephaly, mental retardation, miscarriages, and aging. Over the last century, Drosophila has provided a valuable system for studying the consequences of systemic aneuploidies. More recently, it has contributed to the identification and molecular dissection of aneuploidy-induced cellular behaviors and their impact at the tissue and organismal levels. In this perspective, we review this active field of research, first by comparing knowledge from yeast, mouse, and human cells, then by highlighting the contributions of Drosophila. The aim of these discussions was to further our understanding of the functional interplay between aneuploidy, cell physiology, and tissue homeostasis in human development and disease. |
Note: | https://doi.org/10.1016/j.devcel.2023.12.009 |
It is part of: | Developmental Cell, 2024, 59, 3, 295-307 |
URI: | http://hdl.handle.net/2445/212564 |
Related resource: | https://doi.org/10.1016/j.devcel.2023.12.009 |
ISSN: | Joy, J; Fusari, E; Milan, M (2024). Aneuploidy-induced cellular behaviors Insights from<i> Drosophila</i>. Developmental Cell, 59(3), 295-307. DOI: 10.1016/j.devcel.2023.12.009 6608449 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Joy_Fusari and Milan_Developmental Cell_2024.pdf | 1.2 MB | Adobe PDF | View/Open Request a copy |
Document embargat fins el
5-2-2025
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.