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http://hdl.handle.net/2445/212742
Title: | The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis |
Author: | Mortimer, Thomas Zinna, Valentina Maria ATALAY, Müge Laudanna, Carmelo Deryagin, Oleg POSAS SOLANES, Guillem Smith, Jacob G. García-Lara, Elisa Vaca-Dempere, Mireia Monteiro de Assis, Leonardo Vinícius Heyde, Isabel Koronowski, Kevin B. Petrus, Paul Greco, Carolina M. Forrow, Stephen Oster, Henrik Sassone-Corsi, Paolo Welz, Patrick-Simon Munoz-Canoves, Pura Aznar Benitah, Salvador |
Keywords: | Cell & tissue engineering Cell biology Ciências biológicas ii General medicine Genetics Medicina i Medicina ii Medicina veterinaria Molecular medicine |
Issue Date: | 2-May-2024 |
Publisher: | Elsevier |
Abstract: | In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain signals to ensure timely execution of epidermal daily physiology. Timely cell-cycle termination in the epidermal stem cell compartment depends upon incorporation of clock-driven signals originating from the brain. In contrast, the epidermal clock corrects or outcompetes potentially disruptive feeding-related signals to ensure the optimal timing of DNA replication. Together, we present an approach for cataloging the systemic dependencies of daily temporal organization in a tissue and identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis. |
Note: | https://doi.org/10.1016/j.stem.2024.04.013 |
It is part of: | Cell Stem Cell, 2024, |
URI: | http://hdl.handle.net/2445/212742 |
Related resource: | https://doi.org/10.1016/j.stem.2024.04.013 |
ISSN: | Mortimer, Thomas; Zinna, Valentina M.; Atalay, Muge; Laudanna, Carmelo; Deryagin, Oleg; Posas, Guillem; Smith, Jacob G.; García-Lara, Elisa; Vaca-Demp (2024). The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis. Cell Stem Cell, (), -. DOI: 10.1016/j.stem.2024.04.013 6609780 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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