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http://hdl.handle.net/2445/213223Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Colomer, Jordi | - |
| dc.contributor.author | Lozano Gargallo, Clàudia | - |
| dc.date.accessioned | 2024-06-14T15:24:24Z | - |
| dc.date.available | 2024-06-14T15:24:24Z | - |
| dc.date.issued | 2024-06-05 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/213223 | - |
| dc.description | Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2023-2024. Tutor/Director: Jordi Colomer ; Director: Jordi Abante | ca |
| dc.description.abstract | brain regions,particularlyaffectingthestriatalneuronsknownasMediumSpinyNeurons(MSNs). Unfortunately,neuronsdonotregenerate,thus,makingitimpossibleforthebodytoreplacetheir function. Despiteextensiveresearch,thereiscurrentlynocureforHD,andthegoaloftreatmentis to alleviatesymptoms. Stem celltherapyrepresentsapromisingdirection,allowingindefinite in vitro cells expansionand differentiationintothedesiredtargetneurons.Themainlimitationofneuralcellstransplantisthat once theirprojectionsaregrown,theycannotbedetractedfromthecultureplatewithoutbreaking and causingcelldeath. In thisproject,wefocusonidentifyingtheoptimaltargetprogenitorsubpopulation.Thecellsshould be matureenoughtoexclusivelydifferentiateintoMSNsbutyetnotoverlymature,preventingthe development oftheprojectionsthatleadtocelldeathuponbreaking.Leveragingcomputational genomics, weanalyzehumansingle-cellRNAsequencingdatatocharacterizetheMSNdifferen- tiation process.Integrating in vivo and in vitro data, wegroupcellsindifferentclustersdepending on theirgeneticexpressionandcomputetheirvelocitiestoanalysetheirfate.Ourfindingsreveala potential groupofcellsthatseemtofulfillallthecriteria.Additionally,theprojecthasenabledthe characterization ofthedifferentlineagesofcellswithinthedifferentiationprocessofstriatalneurons. | ca |
| dc.format.extent | 72 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | ca |
| dc.rights | cc-by-nc-nd (c) Clàudia Lozano Gargallo, 2024 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
| dc.source | Treballs Finals de Grau (TFG) - Enginyeria Biomèdica | - |
| dc.subject.classification | Enginyeria biomèdica | - |
| dc.subject.classification | Materials biomèdics | - |
| dc.subject.classification | Treballs de fi de grau | - |
| dc.subject.other | Biomedical engineering | - |
| dc.subject.other | Biomedical materials | - |
| dc.subject.other | Bachelor's theses | - |
| dc.title | Leveraging single-cell genomics for cell therapy in Huntington's disease | ca |
| dc.type | info:eu-repo/semantics/bachelorThesis | ca |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
| Appears in Collections: | Treballs Finals de Grau (TFG) - Enginyeria Biomèdica | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| TFG_Lozano_Gargallo_Claudia.pdf | 8.79 MB | Adobe PDF | View/Open |
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