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Title: | Association between endocrine and neuropsychological endophenotypes and gambling disorder severity |
Author: | Mora Maltas, Bernat Baenas, Isabel Etxandi, Mikel Lucas, Ignacio Granero, Roser Fernández Aranda, Fernando Tovar, Sulay Solé Morata, Neus Gómez Peña, Mónica Moragas, Laura del Pino-Gutiérrez, A. Tapia, Javier Dieguez, Carlos Goudriaan, A.E. Jimenez Murcia, Susana |
Keywords: | Fenotip Joc compulsiu Hormones Impulsos (Psicologia) Phenotype Compulsive gambling Hormones Impulse |
Issue Date: | 1-Jun-2024 |
Publisher: | Elsevier Ltd |
Abstract: | Background: Neurobiological characteristics have been identified regarding the severity of gambling disorder (GD). The aims of this study were: (1) to examine, through a path analysis, whether there was a relationship between neuroendocrine features, potentially mediational GD variables, and GD severity, and (2) to associate neuroendocrine variables, with GD severity-related variables according to gambling preferences. Methods: The sample included 297 outpatients with GD. We analyzed endocrine concentrations of different appetite-related hormones (ghrelin, liver antimicrobial peptide 2 [LEAP-2], leptin, adiponectin), and neuropsychological performance (working memory, cognitive flexibility, inhibition, decision making, premorbid intelligence). Path analysis assessed mechanisms between neuroendocrine features and GD severity, including mediational GD variables (impulsivity traits and gambling-related cognitive distortions). Partial correlations evaluated the associations between neuroendocrine variables, including impulsivity traits, and variables related to GD severity (DSM-5, South Oaks Gambling Screen, illness duration, and gambling-related cognitive distortions). Results: Lower adiponectin concentrations predicted greater GD severity, while higher LEAP-2 concentrations predicted more gambling-related cognitive distortions. Likewise, better neuropsychological performance directly predicted GD severity, but worse neuropsychological performance was associated with GD severity through the mediational variables of impulsivity traits and gambling-related cognitive distortions. Also, in non-strategic individuals with GD, poor working memory was associated with gambling expectancies and predictive control. In strategic individuals with GD, poor cognitive flexibility was associated with illusion of control, predictive control, and inability to stop gambling. Conclusions: These results provide updated information about the comprehension of the interaction between neuroendocrine features, clinical variables, and severity of GD. Thus, neurobiological functions seem to be strongly related to GD severity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.addbeh.2024.107968 |
It is part of: | Addictive Behaviors, 2024, vol. 153, 107968 |
URI: | http://hdl.handle.net/2445/213445 |
Related resource: | https://doi.org/10.1016/j.addbeh.2024.107968 |
ISSN: | 0306-4603 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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