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http://hdl.handle.net/2445/213647
Title: | Brain-muscle communication prevents muscle aging by maintaining daily physiology |
Author: | Kumar, Arun Vaca Dempere, Mireia Mortimer, Thomas Deryagin, Oleg Smith, Jacob G. Petrus, Paul Koronowski, Kevin B. Greco, Carolina M. Segalés, Jessica Andrés, Eva Lukesova, Vera Zinna, Valentina Maria Welz, Patrick Serrano, Antonio L. Perdiguero, Eusebio Sassone-Corsi, Paolo Aznar Benitah, Salvador Muñoz Cánoves, Pura |
Keywords: | Envelliment Homeòstasi Aging Homeostasis |
Issue Date: | 2-May-2024 |
Abstract: | A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1126/science.adj8533 |
It is part of: | Science, 2024, vol. 384, num. 6695, p. 563-572 |
URI: | http://hdl.handle.net/2445/213647 |
Related resource: | https://doi.org/10.1126/science.adj8533 |
ISSN: | 1095-9203 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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Kumar_Science_2024_preprint2.pdf | 3.17 MB | Adobe PDF | View/Open |
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