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Title: Generation of biological association networks: A novel strategy to detect new targets in cancer therapy
Author: Selga i Coma, Elisabet
Almagro García, Ma. Cristina de
Oleaga Sancho, Carlota
Mencía Trinchant, Núria
Ramírez, Sara
Ruiz, F. Xavier
Farrés i Vicén, Jaume
Parés i Casasampera, Xavier
Thibaut, Rémi
Porte Visa, Cinta
Noé Mata, Verónica
Ciudad i Gómez, Carlos Julián
Keywords: Càncer
Issue Date: 2011
Publisher: Transworld Research Network
Abstract: The aim of this work was to design a novel strategy to detect new targets for anticancer treatments. The rationale was to build Biological Association Networks from differentially expressed genes in drug-resistant cells to identify important nodes within the Networks. These nodes may represent putative targets to attack in cancer therapy, as a way to destabilize the gene network developed by the resistant cells to escape from the drug pressure. As a model we used cells resistant to methotrexate (MTX), an inhibitor of DHFR. Selected node-genes were analyzed at the transcriptional level and from a genotypic point of view. In colon cancer cells, DHFR, the AKR1 family, PKC¿, S100A4, DKK1, and CAV1 were overexpressed while E-cadherin was lost. In breast cancer cells, the UGT1A family was overexpressed, whereas EEF1A1 was overexpressed in pancreatic cells. Interference RNAs directed against these targets sensitized cells towards MTX.
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Note: Reproducció del capítol 1 del llibre publicat a:
It is part of: Recent Advances in Pharmaceutical Sciences, 2011, Chapter 1, p. 1-33. Editor: Diego Muñoz-Torrero
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Appears in Collections:Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular)

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