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dc.contributor.author | Westin, Shannon N. | - |
dc.contributor.author | Moore, Kathleen | - |
dc.contributor.author | Chon, Hye Sook | - |
dc.contributor.author | Lee, Jung-yun | - |
dc.contributor.author | Thomes Pepin, Jessica | - |
dc.contributor.author | Sundborg, Michael | - |
dc.contributor.author | Shai, Ayelet | - |
dc.contributor.author | De La Garza, Joseph | - |
dc.contributor.author | Nishio, Shin | - |
dc.contributor.author | Gold, Michael A. | - |
dc.contributor.author | Wang, Ke | - |
dc.contributor.author | Mcintyre, Kristi | - |
dc.contributor.author | Tillmanns, Todd D. | - |
dc.contributor.author | Blank, Stephanie V. | - |
dc.contributor.author | Liu, Ji-hong | - |
dc.contributor.author | Mccollum, Michael | - |
dc.contributor.author | Contreras Mejia, Fernando | - |
dc.contributor.author | Nishikawa, Tadaaki | - |
dc.contributor.author | Pennington, Kathryn | - |
dc.contributor.author | Novak, Zoltan | - |
dc.contributor.author | De Melo, Andreia Cristina | - |
dc.contributor.author | Sehouli, Jalid | - |
dc.contributor.author | Klasa-mazurkiewicz, Dagmara | - |
dc.contributor.author | Papadimitriou, Christos | - |
dc.contributor.author | Gil-martin, Marta | - |
dc.contributor.author | Brasiuniene, Birute | - |
dc.contributor.author | Donnelly, Conor | - |
dc.contributor.author | Del Rosario, Paula Michelle | - |
dc.contributor.author | Liu, Xiaochun | - |
dc.contributor.author | Van Nieuwenhuysen, Els | - |
dc.contributor.author | Frentzas, Sophia | - |
dc.contributor.author | Ganessan, Kichendasse | - |
dc.contributor.author | Gao, Bo | - |
dc.contributor.author | Meniawy, Tarek | - |
dc.contributor.author | Mileshkin, Linda | - |
dc.contributor.author | Richardson, Gary | - |
dc.contributor.author | Roncolato, Felicia | - |
dc.contributor.author | Baurain, Jean-francois | - |
dc.contributor.author | Bourhaba, Maryam | - |
dc.contributor.author | De Cuypere, Eveline | - |
dc.contributor.author | Debruyne, Philip | - |
dc.contributor.author | Denys, Hannelore | - |
dc.contributor.author | Forget, Frederic | - |
dc.contributor.author | Honhon, Brigitte | - |
dc.contributor.author | Joosens, Eric | - |
dc.contributor.author | Van Nieuwenhuysen, Els | - |
dc.contributor.author | Da Costa Miranda, Vanessa | - |
dc.contributor.author | De Melo, Andreia Cristina | - |
dc.contributor.author | Guedes, Joao Daniel | - |
dc.contributor.author | Joseph De Padua, Charles Andree | - |
dc.contributor.author | Lazaretti, Nicolas | - |
dc.contributor.author | Vieira, Carolina Martins | - |
dc.contributor.author | Mattar, Andre | - |
dc.contributor.author | Palmeiro, Daniela Neves | - |
dc.contributor.author | Oppermann Kussler, Christina Pimentel | - |
dc.contributor.author | Rubini Liedke, Pedro Emanuel | - |
dc.contributor.author | Nunes, Joao Soares | - |
dc.contributor.author | Tiscoski, Katsuki Arima | - |
dc.contributor.author | Covens, Allan | - |
dc.contributor.author | De Guerke, Lara | - |
dc.contributor.author | Ghatage, Prafull | - |
dc.contributor.author | Gilbert, Lucy | - |
dc.contributor.author | Lau, Susie | - |
dc.contributor.author | Oza, Amit | - |
dc.contributor.author | Provencher, Diane | - |
dc.contributor.author | Touhami, Omar | - |
dc.contributor.author | Congzhu, Li | - |
dc.contributor.author | Danbo, Wang | - |
dc.contributor.author | Ge, Lou | - |
dc.contributor.author | Gen-hai, Zhu | - |
dc.contributor.author | Guiling, Li | - |
dc.contributor.author | Hong, Shi | - |
dc.contributor.author | Hong, Zheng | - |
dc.contributor.author | Hongwu, Wen | - |
dc.contributor.author | Ji-hong, Liu | - |
dc.contributor.author | Jing, Wang | - |
dc.contributor.author | Ke, Wang | - |
dc.contributor.author | Kui, Jiang | - |
dc.contributor.author | Li, Li | - |
dc.contributor.author | Li, Wang | - |
dc.contributor.author | Min, Hao | - |
dc.contributor.author | Qi, Zhou | - |
dc.contributor.author | Qinglei, Gao | - |
dc.contributor.author | Sihai, Liao | - |
dc.contributor.author | Songling, Zhang | - |
dc.contributor.author | Weidong, Zhao | - |
dc.contributor.author | Wu, Xiaohua | - |
dc.contributor.author | Wuliang, Wang | - |
dc.contributor.author | Yin, Rutie | - |
dc.contributor.author | Ying, Cheng | - |
dc.contributor.author | Yu, Zhang | - |
dc.contributor.author | Zhiqing, Liang | - |
dc.contributor.author | Mejia, Fernando Contreras | - |
dc.contributor.author | Hernandez, Angel Luis | - |
dc.contributor.author | Lopez, Carolina Ortiz | - |
dc.contributor.author | Pacheco, Carlos Javier | - |
dc.contributor.author | Ramos Guette, Pedro Luis | - |
dc.contributor.author | Pereira, Jaime Rendon | - |
dc.contributor.author | Diaz, Julian Rivera | - |
dc.contributor.author | Villegas, Tomas Sanchez | - |
dc.contributor.author | Suso, Juan Pablo | - |
dc.contributor.author | Torregroza Otero, Marco Antonio | - |
dc.contributor.author | Grisan, Karin | - |
dc.contributor.author | Vettus, Elen | - |
dc.contributor.author | Aktas, Bahriye | - |
dc.contributor.author | Egger, Eva | - |
dc.contributor.author | Krabisch, Petra | - |
dc.contributor.author | Muller, Andreas | - |
dc.contributor.author | Rom, Joachim | - |
dc.contributor.author | Sehouli, Jalid | - |
dc.contributor.author | Sperfeld, Antje | - |
dc.contributor.author | Wimberger, Pauline | - |
dc.contributor.author | Zorr, Andreas | - |
dc.contributor.author | Fountzilas, George | - |
dc.contributor.author | Karageorgopoulou, Sofia | - |
dc.contributor.author | Papadimitriou, Christos | - |
dc.contributor.author | Psyrri, Amanda | - |
dc.contributor.author | Zagour, Florai | - |
dc.contributor.author | Loen Chan, Karen Kar | - |
dc.contributor.author | Ho, Wing Ming | - |
dc.contributor.author | Csoszi, Tibor | - |
dc.contributor.author | Landherr, Laszlo | - |
dc.contributor.author | Novak, Zoltan | - |
dc.contributor.author | Papai, Zsuzsanna | - |
dc.contributor.author | Poka, Robert | - |
dc.contributor.author | Sipocz, Istvan | - |
dc.contributor.author | Devinder, Paul | - |
dc.contributor.author | Goyal, Lovenish | - |
dc.contributor.author | Gupta, Sudeep | - |
dc.contributor.author | Naik, Radheshyam | - |
dc.contributor.author | Patil, Tushar | - |
dc.contributor.author | Somashekhar, S.p. | - |
dc.contributor.author | Bruchim, Ilan | - |
dc.contributor.author | Kovel, Svetlana | - |
dc.contributor.author | Leibovici, Anca | - |
dc.contributor.author | Rosengarten, Ora | - |
dc.contributor.author | Safra, Tamar | - |
dc.contributor.author | Yamagami, Wataru | - |
dc.contributor.author | Hamanishi, Junzo | - |
dc.contributor.author | Imai, Yuichi | - |
dc.contributor.author | Kado, Nobuhiro | - |
dc.contributor.author | Kamiura, Shoji | - |
dc.contributor.author | Kato, Hienori | - |
dc.contributor.author | Kondo, Eiji | - |
dc.contributor.author | Kudaka, Wataru | - |
dc.contributor.author | Matsumoto, Takashi | - |
dc.contributor.author | Mori, Masahiko | - |
dc.contributor.author | Nishikawa, Tadaaki | - |
dc.contributor.author | Nishio, Shin | - |
dc.contributor.author | Okamoto, Aikou | - |
dc.contributor.author | Yunokawa, Mayu | - |
dc.contributor.author | Sekine, Masayuki | - |
dc.contributor.author | Sumi, Toshiyuki | - |
dc.contributor.author | Takano, Hirokuni | - |
dc.contributor.author | Takehara, Kazuhiro | - |
dc.contributor.author | Brasiuniene, Birute | - |
dc.contributor.author | Inciura, Arturas | - |
dc.contributor.author | Jonuskiene, Goda | - |
dc.contributor.author | Cabrera Luviano, Jesus Elvis | - |
dc.contributor.author | Dominguez-andrade, Adriana | - |
dc.contributor.author | Gerson-cwilich, Raquel | - |
dc.contributor.author | Hernandez, Carlos Hernandez | - |
dc.contributor.author | Hernandez, Jesus Lopez | - |
dc.contributor.author | Martinez Lira, Jose Luis | - |
dc.contributor.author | Navarrete Aleman, Jaime Esteban | - |
dc.contributor.author | Contreras, Jessica Reyes | - |
dc.contributor.author | Camargo, Vanessa Rosas | - |
dc.contributor.author | Bednarek, Wieslawa | - |
dc.contributor.author | Klasa-mazurkiewicz, Dagmara | - |
dc.contributor.author | Kubiatowski, Tomasz | - |
dc.contributor.author | Potemski, Piotr | - |
dc.contributor.author | Sikorska, Magdalena | - |
dc.contributor.author | Chang, Suk-joon | - |
dc.contributor.author | Hong, Sook Hee | - |
dc.contributor.author | Kang, Sokbom | - |
dc.contributor.author | Kim, Byoung-gie | - |
dc.contributor.author | Kim, Jan-weon | - |
dc.contributor.author | Kim, Yong Man | - |
dc.contributor.author | Lee, Jung-yun | - |
dc.contributor.author | Ryu, Sang Young | - |
dc.contributor.author | Song, Yong Jung | - |
dc.contributor.author | Kirtbaya, Dmitriy | - |
dc.contributor.author | Kreynina, Julya | - |
dc.contributor.author | Lisyanskaya, Alla | - |
dc.contributor.author | Makarova, Yulia | - |
dc.contributor.author | Orlova, Rashida | - |
dc.contributor.author | Pirmagomedov, Albert | - |
dc.contributor.author | Saevets, Valeria | - |
dc.contributor.author | Safina, Sufia | - |
dc.contributor.author | Skopin, Pavel | - |
dc.contributor.author | Tyulyandina, Alexandra | - |
dc.contributor.author | Lim, Sheow Lei | - |
dc.contributor.author | Su Mien, Lynette Ngo | - |
dc.contributor.author | Shao Peng, David Tan | - |
dc.contributor.author | Soh, Lay Tin | - |
dc.contributor.author | Company, Jesus Alarcon | - |
dc.contributor.author | Barretina, Pilar | - |
dc.contributor.author | Estevez-garcia, Purificacion | - |
dc.contributor.author | Perez, Isaura Fernandez | - |
dc.contributor.author | Galvez, Fernando | - |
dc.contributor.author | Garcia, Yolanda | - |
dc.contributor.author | Gil-martin, Marta | - |
dc.contributor.author | Martinez, Jeronimo | - |
dc.contributor.author | Redondo-sanchez, Andres | - |
dc.contributor.author | Anderson, Charles | - |
dc.contributor.author | Berman, Tara | - |
dc.contributor.author | Blank, Stephanie | - |
dc.contributor.author | Bradley, William | - |
dc.contributor.author | Burke, James | - |
dc.contributor.author | Cappuccini, Fabio | - |
dc.contributor.author | Carney, Michael | - |
dc.contributor.author | Chambers, Setsuko | - |
dc.contributor.author | Chen, Lee-may | - |
dc.contributor.author | Chon, Hye Sook | - |
dc.contributor.author | Garza, Joseph De La | - |
dc.contributor.author | Depasquale, Stephen | - |
dc.contributor.author | Disilvestro, Paul | - |
dc.contributor.author | Edraki, Babak | - |
dc.contributor.author | Fleming, Evelyn | - |
dc.contributor.author | Fox, Jenny | - |
dc.contributor.author | Gold, Michael | - |
dc.contributor.author | Gordinier, Mary | - |
dc.contributor.author | Guy, Michael | - |
dc.contributor.author | Hartenbach, Ellen | - |
dc.contributor.author | Haygood, Chisten | - |
dc.contributor.author | Jordan, Scott | - |
dc.contributor.author | Kilgore, Larry | - |
dc.contributor.author | Kim, Young | - |
dc.contributor.author | Lucci, Joseph | - |
dc.contributor.author | Mccollum, Michael | - |
dc.contributor.author | Mchale, Michael | - |
dc.contributor.author | Mcintyre, Kristi | - |
dc.contributor.author | Messing, Mark | - |
dc.contributor.author | Miller, Eirwen | - |
dc.contributor.author | Moore, Kathleen | - |
dc.contributor.author | Moroney, John | - |
dc.contributor.author | Onstad, Michaela | - |
dc.contributor.author | Ortiz, Taylor | - |
dc.contributor.author | Ozair, Sobia | - |
dc.contributor.author | Pennington, Kathryn | - |
dc.contributor.author | Pfaendler, Krista | - |
dc.contributor.author | Priebe, Anna | - |
dc.contributor.author | Pustilnik, Terri | - |
dc.contributor.author | Resnick, Kimberly | - |
dc.contributor.author | Rose, Peter | - |
dc.contributor.author | Salinas, Erin | - |
dc.contributor.author | Sharma, Sudarshan | - |
dc.contributor.author | Sobol, Urszula | - |
dc.contributor.author | Soliman, Pamela | - |
dc.contributor.author | Starks, David | - |
dc.contributor.author | Sundborg, Michael | - |
dc.contributor.author | Teplinsky, Eleonora | - |
dc.contributor.author | Thomes-pepin, Jessica | - |
dc.contributor.author | Tillmanns, Todd | - |
dc.contributor.author | Warshal, David | - |
dc.contributor.author | Westin, Shannon N. | - |
dc.contributor.author | Woliver, Thomas | - |
dc.date.accessioned | 2024-07-01T09:07:42Z | - |
dc.date.available | 2024-07-01T09:07:42Z | - |
dc.date.issued | 2024-01-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214044 | - |
dc.description.abstract | PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Clinical Oncology (ASCO) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1200/JCO.23.02132 | - |
dc.relation.ispartof | Journal of Clinical Oncology, 2024, vol. 42, issue. 3, p. 283-299 | - |
dc.relation.uri | https://doi.org/10.1200/JCO.23.02132 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.title | Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2024-06-28T11:02:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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westin-et-al-2023-durvalumab-plus-carboplatin-paclitaxel-followed-by-maintenance-durvalumab-with-or-without-olaparib-as.pdf | 1.54 MB | Adobe PDF | View/Open |
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