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http://hdl.handle.net/2445/214055
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DC Field | Value | Language |
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dc.contributor.author | Escalera, Alba | - |
dc.contributor.author | Rojo-fernandez, Amaya | - |
dc.contributor.author | Rombauts, Alexander | - |
dc.contributor.author | Abelenda-alonso, Gabriela | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | García-sastre, Adolfo | - |
dc.contributor.author | Aydillo, Teresa | - |
dc.date.accessioned | 2024-07-01T15:06:09Z | - |
dc.date.available | 2024-07-01T15:06:09Z | - |
dc.date.issued | 2024-03-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214055 | - |
dc.description.abstract | Despite multiple research efforts to characterize coronavirus disease 2019 (COVID-19) in humans, there is no clear data on the specific role of mucosal immunity on COVID-19 disease. Here, we longitudinally profile the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and seasonal HCoV-OC43 S proteins in serum and nasopharyngeal swabs from COVID-19 patients. Results showed that specific antibody responses against SARS-CoV-2 and HCoV-OC43 S proteins can be detected in the upper respiratory tract. We found that COVID-19 patients mounted a robust mucosal antibody response against SARS-CoV-2 S with specific secretory immunoglobulin A (sIgA), IgA, IgG, and IgM antibody subtypes detected in the nasal swabs. Additionally, COVID-19 patients showed IgG, IgA, and sIgA responses against HCoV-OC43 S in the local mucosa, whereas no specific IgM was detected. Interestingly, mucosal antibody titers against SARS-CoV-2 peaked at day 7, whereas HCoV-OC43 titers peaked earlier at day 3 post -recruitment, suggesting an immune memory recall to conserved epitopes of beta-HCoVs in the upper respiratory tract. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.isci.2024.109210 | - |
dc.relation.ispartof | iScience, 2024, vol. 27, issue. 3, p. 109210 | - |
dc.relation.uri | https://doi.org/10.1016/j.isci.2024.109210 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.title | SARS-CoV-2 infection induces robust mucosal antibody responses in the upper respiratory tract | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2024-06-14T09:43:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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PIIS2589004224004310.pdf | 3.4 MB | Adobe PDF | View/Open |
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