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http://hdl.handle.net/2445/214067
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DC Field | Value | Language |
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dc.contributor.author | Oblitas, Crhistian Mario | - |
dc.contributor.author | Demelo Rodríguez, Pablo | - |
dc.contributor.author | Álvarez-Sala Walther, Luis Antonio | - |
dc.contributor.author | Rubio Rivas, Manuel | - |
dc.contributor.author | Navarro Romero, Francisco | - |
dc.contributor.author | Giner Galvañ, Vicente | - |
dc.contributor.author | Jorge Huerta, Lucía de | - |
dc.contributor.author | Fonseca Aizpuru, Eva | - |
dc.contributor.author | García García, Gema María | - |
dc.contributor.author | Beato Pérez, José Luis | - |
dc.contributor.author | Pesqueira Fontan, Paula María | - |
dc.contributor.author | Artero Mora, Arturo | - |
dc.contributor.author | Vargas Núñez, Juan Antonio | - |
dc.contributor.author | Ramírez Perea, Nuria | - |
dc.contributor.author | García Bruñén, José Miguel | - |
dc.contributor.author | Roy Vallejo, Emilia | - |
dc.contributor.author | Perales Fraile, Isabel | - |
dc.contributor.author | Gil Sánchez, Ricardo | - |
dc.contributor.author | López Castro, José | - |
dc.contributor.author | Martínez González, Ángel Luis | - |
dc.contributor.author | Díez García, Luis Felipe | - |
dc.contributor.author | Aroza Espinar, Marina | - |
dc.contributor.author | Casas Rojo, José Manuel | - |
dc.contributor.author | Millán Núñez-Cortés, Jesús | - |
dc.date.accessioned | 2024-07-01T15:03:48Z | - |
dc.date.available | 2024-07-01T15:03:48Z | - |
dc.date.issued | 2024-02-22 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214067 | - |
dc.description.abstract | Background: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: A total of 10,575 COVID-19 patients were included in this study. The mean age of participants was 66.9 (+/- 16) years, and 58.6% (6202 patients) of them were male. The overall mortality rate was 16.3% (n = 1726 patients). Intensive care unit admission was needed in 10.5% (n = 1106 patients), non-invasive mechanical ventilation was required in 8.8% (n = 923 patients), and orotracheal intubation was required in 7.5% (789 patients). DLR presented a c-statistic of 0.69 (95% CI, 0.68-0.71) for in-hospital mortality with an optimal cut-off above 1. Multivariate analysis showed an independent association for in-hospital mortality for DLR > 1 (adjusted OR 2.09, 95% CI 1.09-4.04; p = 0.03); in the same way, survival analysis showed a higher mortality risk for DLR > 1 (HR 2.24; 95% CI 2.03-2.47; p < 0.01). Further, no other laboratory indices showed an independent association for mortality in multivariate analysis. Conclusions: This study confirmed the usefulness of DLR as a prognostic biomarker for mortality associated with SARS-CoV-2 infection, being an accessible, cost-effective, and easy-to-use biomarker in daily clinical practice. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/v16030335 | - |
dc.relation.ispartof | Viruses, 2024, vol. 16, num. 3 | - |
dc.relation.uri | https://doi.org/10.3390/v16030335 | - |
dc.rights | cc by (c) Oblitas, Crhistian Mario et al, 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties immunitàries | - |
dc.subject.classification | COVID-19 | - |
dc.subject.other | Immunologic diseases | - |
dc.subject.other | COVID-19 | - |
dc.title | Prognostic Value of D-dimer to Lymphocyte Ratio (DLR) in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients: A Validation Study in a National Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-06-14T09:30:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38543700 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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viruses-16-00335-v2.pdf | 844.38 kB | Adobe PDF | View/Open |
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