Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/214184
Title: | Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives |
Author: | Sirico, Marianna Virga, Alessandra Conte, Benedetta Urbini, Milena Ulivi, Paola Gianni, Caterina Merloni, Filippo Palleschi, Michela Gasperoni, Marco Curcio, Annalisa Saha, Debjani Buono, Giuseppe Muñoz, Montserrat De Giorgi, Ugo Schettini, Francesco |
Keywords: | Càncer de mama Marcadors bioquímics Endocrinologia Tractament adjuvant del càncer Breast cancer Biochemical markers Endocrinology Adjuvant treatment of cancer |
Issue Date: | 1-Jan-2023 |
Publisher: | Elsevier |
Abstract: | Neoadjuvant endocrine treatment (NET) associates to satisfactory rates of breast conservative surgery and conversions from inoperable to operable hormone receptor-positive (HR+)/HER2-negative breast cancer (BC), with less toxicities than neoadjuvant chemotherapy (NACT) and similar outcomes. Hence, it has been proposed as a logical alternative to NACT in patients with HR+/HER2- BC candidate to a neoadjuvant approach. Nevertheless, potential barriers to the widespread use of NET include the heterogeneous nature of patient response coupled with the long duration needed to achieve a clinical response. However, interest in NET has significantly increased in the last decade, owing to more in-depth investigation of several biomarkers for a more adequate patient selection and on-treatment benefit monitoring, such as PEPI score, Ki67 and genomic assays. This review is intended to describe the state-of-the-art regarding NET, its future perspectives and potential integration with molecular biomarkers for the optimal selection of patients, regimen and duration of (neo)adjuvant treatments. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.critrevonc.2022.103900 |
It is part of: | Critical Reviews in Oncology Hematology, 2023, vol. 181 |
URI: | http://hdl.handle.net/2445/214184 |
Related resource: | https://doi.org/10.1016/j.critrevonc.2022.103900 |
ISSN: | 1040-8428 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
256609.pdf | 644.52 kB | Adobe PDF | View/Open | |
Corrigendum Neoadjuvant endocrine therapy.pdf | 257.85 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License