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http://hdl.handle.net/2445/214253
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DC Field | Value | Language |
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dc.contributor.author | Rodríguez, Laura G. | - |
dc.contributor.author | Delgado, Ana | - |
dc.contributor.author | Ciudad i Gómez, Carlos Julián | - |
dc.contributor.author | Noé Mata, Verónica | - |
dc.contributor.author | Bonjoch i Sesé, Josep | - |
dc.contributor.author | Bradshaw, Ben | - |
dc.date.accessioned | 2024-07-03T17:10:09Z | - |
dc.date.available | 2024-07-03T17:10:09Z | - |
dc.date.issued | 2022-11-03 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214253 | - |
dc.description.abstract | A Diels-Alder reaction leading to 4-nitrophenylcyclohexanones followed by a newly developed base-mediated reductive cyclization of the resulting ketone tethered to the nitrobenzene moiety gives access to the hexahydro-2,6-methano-1-benzazocine ring system present in several biologically interesting natural products such as aspernomine. The scope of the reaction was explored with eight substituted nitrobenzenes, obtaining yields of up to 87%. The highest cytotoxicity was observed in benzazocine 4h, bearing an enone moiety, which was active against eight cancer cell lines. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1021/acs.joc.2c02205 | - |
dc.relation.ispartof | Journal of Organic Chemistry, 2022, vol. 87, num.22, p. 15693-15702 | - |
dc.relation.uri | https://doi.org/10.1021/acs.joc.2c02205 | - |
dc.rights | cc by (c) American Chemical Society, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Hidrocarburs | - |
dc.subject.classification | Cromatografia | - |
dc.subject.classification | Purificació | - |
dc.subject.other | Hydrocarbons | - |
dc.subject.other | Chromatography | - |
dc.subject.other | Purification | - |
dc.title | Base-Mediated Nitrophenyl Reductive Cyclization for the Synthesis of Hexahydro-2,6-methano-1-benzazocines | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 728760 | - |
dc.date.updated | 2024-07-03T17:10:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Bioquímica i Fisiologia) |
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File | Description | Size | Format | |
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255777.pdf | 1.88 MB | Adobe PDF | View/Open |
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