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http://hdl.handle.net/2445/214269
Title: | Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer |
Author: | Carrasco, Raquel Ingelmo-Torres, Mercedes Gómez, Ascensión Roldán, Fiorella L. Segura, Natalia Ribal, María José Alcaraz Asensio, Antonio Izquierdo Reyes, Laura Mengual Brichs, Lourdes |
Keywords: | Pronòstic mèdic Urologia Càncer de bufeta Marcadors tumorals Prognosis Urology Bladder cancer Tumor markers |
Issue Date: | 17-Jun-2022 |
Publisher: | Springer Verlag |
Abstract: | Purpose: Current clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at high risk of progression after radical cystectomy (RC). Here, we determined genetic alterations in the tumor and circulating tumor cell (CTC) enumeration to find biomarkers useful for the management of MIBC after RC. Methods: Thirty-nine MIBC patients undergoing RC were included. Tumoral tissue DNA was analyzed by next generation sequencing. CTCs were isolated from blood collected before RC and one, four and 12 months later. Results: Sixteen (41%) patients progressed in a median time of 8.5 months and 11 (69%) of these patients harbored the TERT c.-124C > T mutation. All progressive patients harboring the TERT c.-124C > T mutation presented a significant increase in CTC number 12 months after RC compared to those without the mutation. Additionally, CTC number at 12 months was identified as an independent prognostic biomarker for tumor progression and cancer specific survival (CSS). Ten (63%) progressive patients showed an increment of CTC number with a median anticipation period of four months compared with imaging techniques. Conclusions: The TERT c.-124C > T mutation could be considered a biomarker of aggressivity. CTC enumeration is a useful tool for identifying MIBC patients at high risk of progression and CSS after RC and for detecting tumor progression earlier than imaging techniques. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s00345-022-04061-9 |
It is part of: | World Journal of Urology, 2022, vol. 40, num.8, p. 2033-2039 |
URI: | http://hdl.handle.net/2445/214269 |
Related resource: | https://doi.org/10.1007/s00345-022-04061-9 |
ISSN: | 0724-4983 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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