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http://hdl.handle.net/2445/214304
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DC Field | Value | Language |
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dc.contributor.author | Baucells, Benjamin James | - |
dc.contributor.author | Sebastiani, Giorgia | - |
dc.contributor.author | Herrero Aizpurua, Leyre | - |
dc.contributor.author | Andreu-Fernández, Vicente | - |
dc.contributor.author | Navarro Tapia, Elisabet | - |
dc.contributor.author | García Algar, Óscar | - |
dc.contributor.author | Figueras Aloy, José, 1950- | - |
dc.date.accessioned | 2024-07-04T13:30:21Z | - |
dc.date.available | 2024-07-04T13:30:21Z | - |
dc.date.issued | 2023-06-26 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214304 | - |
dc.description.abstract | Probiotics have shown a benefit in reducing necrotising enterocolitis in the premature infant, however the study of their effect on premature neonates' neurodevelopment is limited. The aim of our study was to elucidate whether the effect of Bifidobacterium bifidum NCDO 2203 combined with Lactobacillus acidophilus NCDO 1748 could positively impact the neurodevelopment of the preterm neonates. Quasi-experimental comparative study with a combined treatment of probiotics in premature infants < 32 weeks and < 1500 g birth weight, cared for at a level III neonatal unit. The probiotic combination was administered orally to neonates surviving beyond 7 days of life, until 34 weeks postmenstrual age or discharge. Globally, neurodevelopment was evaluated at 24 months corrected age. A total of 233 neonates were recruited, 109 in the probiotic group and 124 in the non-probiotic group. In those neonates receiving probiotics, there was a significant reduction in neurodevelopment impairment at 2 years of age RR 0.30 [0.16-0.58], and a reduction in the degree of impairment (normal-mild vs moderate-severe, RR 0.22 [0.07-0.73]). Additionally, there was a significant reduction in late-onset sepsis (RR 0.45 [0.21-0.99]). The prophylactic use of this probiotic combination contributed to improving neurodevelopmental outcome and reduced sepsis in neonates born at < 32 weeks and < 1500 g. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-023-37393-6 | - |
dc.relation.ispartof | Scientific Reports, 2023, vol. 13, num.1 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-023-37393-6 | - |
dc.rights | cc-by (c) Baucells, Benjamin James et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Probiòtics | - |
dc.subject.classification | Enterocolitis necrosant del fetus | - |
dc.subject.classification | Infants prematurs | - |
dc.subject.classification | Neurologia dels nadons | - |
dc.subject.other | Probiotics | - |
dc.subject.other | Neonatal necrotizing enterocolitis | - |
dc.subject.other | Premature infants | - |
dc.subject.other | Neonatal neurology | - |
dc.title | Effectiveness of a probiotic combination on the neurodevelopment of the very premature infant | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 749034 | - |
dc.date.updated | 2024-07-04T13:30:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37365274 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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862014.pdf | 1.24 MB | Adobe PDF | View/Open |
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