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Title: | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
Author: | Angelats Canals, Edgar Santamaria Vilanova, Pere |
Keywords: | Biodiversidade Biotecnología Ciência de alimentos Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Engenharias ii Engenharias iii Farmacia Immunology Immunology and allergy Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Odontología Química Saúde coletiva Zootecnia / recursos pesqueiros |
Issue Date: | 25-Sep-2023 |
Abstract: | T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny. |
Note: | https://doi.org/ 10.3389/fimmu.2023.1267697 |
It is part of: | Frontiers In Immunology, 2023, 14, 1267697 |
URI: | http://hdl.handle.net/2445/214354 |
Related resource: | https://doi.org/ 10.3389/fimmu.2023.1267697 |
ISSN: | Angelats, E; Santamaria, P (2023). Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells. Frontiers In Immunology, 14(), 1267697-. DOI: 10.3389/fimmu.2023.1267697 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
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Lineage origin and transcriptional control of autoantigen.pdf | 2.44 MB | Adobe PDF | View/Open |
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