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Title: | Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media |
Author: | Ruiz González, Noelia Esporrín Ubieto, David Lopes Hortelão, Ana Candida Fraire, Juan Bakenecker, Anna Guri Canals, Marta Cugat, Ramon Carrillo, Jose Maria Garcia-Batlletbo, Montserrat Laiz, Patricia Patiño Padial, Tania Sánchez Ordóñez, Samuel |
Keywords: | Astronomia / física Biomaterials Biotechnology Biotecnología Chemistry (all) Chemistry (miscellaneous) Chemistry, multidisciplinary Chemistry, physical Ciências biológicas i Engenharias ii Engineering (miscellaneous) General chemistry General materials science Interdisciplinar Materiais Materials science (all) Materials science (miscellaneous) Materials science, multidisciplinary Medicine (miscellaneous) Nanoscience & nanotechnology Nanoscience and nanotechnology Physics, applied Physics, condensed matter Química |
Issue Date: | 15-Mar-2024 |
Abstract: | Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in the joints is mainly composed of hyaluronic acid (HA). These viscous media pose a challenge for many applications in nanomedicine, as passive NPs tend to become trapped in complex networks, which reduces their ability to reach the target location. This problem can be addressed by using active NPs (nanomotors, NMs) that are self-propelled by enzymatic reactions, although the development of enzyme-powered NMs, capable of navigating these viscous environments, remains a considerable challenge. Here, the synergistic effects of two NMs troops, namely hyaluronidase NMs (HyaNMs, Troop 1) and urease NMs (UrNMs, Troop 2) are demonstrated. Troop 1 interacts with the SF by reducing its viscosity, thus allowing Troop 2 to swim more easily through the SF. Through their collective motion, Troop 2 increases the diffusion of macromolecules. These results pave the way for more widespread use of enzyme-powered NMs, e.g., for treating joint injuries and improving therapeutic effectiveness compared with traditional methods. The conceptual idea of the novel approach using hyaluronidase NMs (HyaNMs) to interact with and reduce the viscosity of the synovial fluid (SF) and urease NMs (UrNMs) for a more efficient transport of therapeutic agents in joints.image |
Note: | https://doi.org/10.1002/smll.202309387 |
It is part of: | Small, 2024, 20, 11, 2309387 |
URI: | http://hdl.handle.net/2445/214494 |
Related resource: | https://doi.org/10.1002/smll.202309387 |
ISSN: | Ruiz-González, N; Esporrín-Ubieto, D; Hortelao, AC; Fraire, JC; Bakenecker, AC; Guri-Canals, M; Cugat, R; Carrillo, JM; Garcia-Batlletbó, M; Laiz, P; (2024). Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media. Small, 20(11), 2309387-. DOI: 10.1002/smll.202309387 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2024_Small_Swarms_SanchezS.pdf | 4.53 MB | Adobe PDF | View/Open |
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