Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/214582
Title: | Immunotherapy in elderly head and neck cancer patients: a systematic review and meta-analysis |
Author: | Salvestrini, Viola Caini, Saverio Scricciolo, Melissa Saerens, Michael Bollen, Heleen Bonomo, Pierluigi Caparrotti, Francesca Lorini, Luigi Oliva, Marc Urbanowicz Nijaki, Maria Szturz, Petr |
Keywords: | Immunoteràpia Cura de les persones grans Immunotheraphy Elderly care |
Issue Date: | 10-May-2024 |
Publisher: | Frontiers Media SA |
Abstract: | Introduction: Over the past years, there has been a growing interest in the role of immunotherapy in locally advanced (LA) and recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). High-quality data from prospective trials are lacking for the elderly subpopulation. This systematic review and meta-analysis aims to review the efficacy and safety of immunotherapy in older patients. Methods: A systematic literature search was conducted. Randomized clinical trials providing outcome data on a subgroup of elderly (>65 years old) were available for meta-analysis. Primary outcomes of interest were OS and PFS for efficacy analysis. Results: Seven studies were included in the systematic review and four in the efficacy analysis. The pooled analysis of OS and PFS showed a consistent benefit (HR 0.78 and 0.91, respectively). Conclusions: Immunotherapy may be an effective and well-tolerated treatment option in the elderly population, but more prospective and randomized data are needed. Systematic Review Registration PROSPERO (CRD42022333891). |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2024.1395838 |
It is part of: | Frontiers in Oncology, 2024, vol. 14 |
URI: | http://hdl.handle.net/2445/214582 |
Related resource: | https://doi.org/10.3389/fonc.2024.1395838 |
ISSN: | 2234-943X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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fonc-14-1395838.pdf | 1.89 MB | Adobe PDF | View/Open |
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