Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/214628
Title: | Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism |
Author: | Balbuena-Pecino, Sara Montblanch, Manel Rosell-Moll, Enrique González-Fernández, Verónica García Meilán, Irene Fontanillas, Ramon Gallardo Romero, María Ángeles Gutiérrez Fruitós, Joaquín Capilla Campos, Encarnación Navarro Álvarez, Isabel |
Keywords: | Orada Polifenols Metabolisme dels lípids Additius de pinsos Sparus aurata Polyphenols Lipid metabolism Feed additives |
Issue Date: | Apr-2024 |
Publisher: | MDPI |
Abstract: | High-fat diets (HFDs) enhance fish growth by optimizing nutrient utilization (i.e., protein-sparing effect); however, their potential negative effects have also encouraged the search for feed additives. This work has investigated the effects of an extract rich in a polyphenolic antioxidant, hydroxytyrosol (HT), supplemented (0.52 g HT/kg feed) in a HFD (24% lipid) in gilthead sea bream (Sparus aurata). Fish received the diet at two ration levels, standard (3% of total fish weight) or restricted (40% reduction) for 8 weeks. Animals fed the supplemented diet at a standard ration had the lowest levels of plasma free fatty acids (4.28 ± 0.23 mg/dL versus 6.42 ± 0.47 in the non-supplemented group) and downregulated hepatic mRNA levels of lipid metabolism markers (ppara, pparb, lpl, fatp1, fabp1, acox1, lipe and lipa), supporting potential fat-lowering properties of this compound in the liver. Moreover, the same animals showed increased muscle lipid content and peroxidation (1.58- and 1.22-fold, respectively, compared to the fish without HT), suggesting the modulation of body adiposity distribution and an enhanced lipid oxidation rate in that tissue. Our findings emphasize the importance of considering this phytocompound as an optimal additive in HFDs for gilthead sea bream to improve overall fish health and condition. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antiox13040403 |
It is part of: | Antioxidants, 2024, vol. 13, num.4, p. 1-21 |
URI: | http://hdl.handle.net/2445/214628 |
Related resource: | https://doi.org/10.3390/antiox13040403 |
ISSN: | 2076-3921 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
859137.pdf | 2.72 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License