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DC Field | Value | Language |
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dc.contributor.author | Rezazadeh, Hamzeh | - |
dc.contributor.author | Ghanati, Faezeh | - |
dc.contributor.author | Bonfill Baldrich, Ma. Mercedes | - |
dc.contributor.author | Nasibi, Fatemeh | - |
dc.contributor.author | Tabarsa, Mehdi | - |
dc.date.accessioned | 2024-07-24T11:30:28Z | - |
dc.date.available | 2024-07-24T11:30:28Z | - |
dc.date.issued | 2024-12-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214709 | - |
dc.description.abstract | <p><em>Alternaria alternata</em> fungus is a potent paclitaxel producer isolated from <em>Corylus avellana</em>. The</p><p>major challenge is the lack of optimized media for endophytic fungi productivity. In the effort to</p><p>maximize the production of taxoids by <em>A. alternata</em>, several fermentation conditions, including pH</p><p>(pH 4.0–7.0), different types and concentrations of carbon (fructose, glucose, sucrose, mannitol,</p><p>sorbitol, and malt extract), and nitrogen (urea, ammonium nitrate, potassium nitrate, ammonium</p><p>phosphate, and ammonium sulfate) were applied step by step. Based on the results, A. alternata in a</p><p>medium containing sucrose 5% (w/v) and ammonium phosphate 2.5 mM at pH 6.0 showed a rapid and</p><p>sustainable growth rate, the highest paclitaxel yield (94.8 μg gFW−1 vs 2.8 μg gFW− 1 in controls), and</p><p>the maximum content of amino acids. Additionally, the effect of pectin was evaluated on fungus, and</p><p>mycelia harvested. Pectin significantly enhanced the growth and taxoid yield on day 21 (respectively</p><p>171% and 116% of their corresponding on day 7). The results were checked out by mathematical</p><p>modeling as well. Accordingly, these findings suggest a low-cost, eco-friendly, and easy-to-produce</p><p>approach with excellent biotechnological potential for the industrial manufacture of taxoids.</p> | - |
dc.format.extent | 1 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: | - |
dc.relation.ispartof | Scientific Reports, 2024, vol. 14, num.1 | - |
dc.rights | cc-by (c) Rezazadeh, H. et al., 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.classification | Fongs | - |
dc.subject.classification | Pectina | - |
dc.subject.other | Fungi | - |
dc.subject.other | Pectin | - |
dc.title | Optimization of the fermentation media, mathematical modeling, and enhancement of paclitaxel production by Alternaria alternata after elicitation with pectin | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 749634 | - |
dc.date.updated | 2024-07-24T11:30:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
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File | Description | Size | Format | |
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864018.pdf | 3.84 MB | Adobe PDF | View/Open |
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