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http://hdl.handle.net/2445/214742
Title: | Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity |
Author: | Miranda Olivos, Romina Baenas, Isabel Steward, Trevor Granero, Roser Pastor, Antoni Sánchez, Isabel Juaneda Seguí, Asier Pino Gutiérrez, Amparo Del Fernández Formoso, Jose A. Vilarrasa, Nuria Guerrero Pérez, Fernando Virgili, Núria López Urdiales, Rafael Jiménez-Murcia, Susana Torre Fornell, Rafael de la Soriano Mas, Carles Fernández Aranda, Fernando (corresponding Author) |
Keywords: | Anorèxia nerviosa Imatges per ressonància magnètica Pes corporal Neurotransmissors Anorexia nervosa Magnetic resonance imaging Body weight Neurotransmitters |
Issue Date: | 28-Sep-2023 |
Publisher: | Nature Publishing Group |
Abstract: | Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; pFWE < 0.001) and the left supplementary motor area (NAcc-SMA; pFWE < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41380-023-02253-2 |
It is part of: | Molecular Psychiatry, 2023, vol. 28, num.11, p. 4793-4800 |
URI: | http://hdl.handle.net/2445/214742 |
Related resource: | https://doi.org/10.1038/s41380-023-02253-2 |
ISSN: | 1359-4184 |
Appears in Collections: | Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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