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http://hdl.handle.net/2445/214806
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DC Field | Value | Language |
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dc.contributor.author | Albert Mach, Joan | - |
dc.contributor.author | Al Janabi, Basma | - |
dc.contributor.author | Granell Sanvicente, Jaime Ramón | - |
dc.contributor.author | Sadat Hashemi, Mojdeh | - |
dc.contributor.author | Sainz García, Daniel | - |
dc.contributor.author | Khosa, M. Kaleem | - |
dc.contributor.author | Calvis, Carme | - |
dc.contributor.author | Messeguer, Ramon | - |
dc.contributor.author | Baldomà Llavinés, Laura | - |
dc.contributor.author | Badía Palacín, Josefa | - |
dc.contributor.author | Font Bardia, Ma. Mercedes | - |
dc.date.accessioned | 2024-08-02T10:49:09Z | - |
dc.date.available | 2024-08-02T10:49:09Z | - |
dc.date.issued | 2022-11-12 | - |
dc.identifier.issn | 0022-328X | - |
dc.identifier.uri | http://hdl.handle.net/2445/214806 | - |
dc.description.abstract | ( E )-2-((4-hydroxybenzylidene)amino)phenol (iminophenol a ) reacted with Pd(OAc) 2 giving place to com- pound 1a , in which the iminophenol was bonded to palladium(II) in a κ3 - C ortho ,N,O ortho tridentate chelat- ing mode. Thus, 1a was formed by neutral mononuclear units of schematic formula Pd(C,N,O), consisting of two fused five-membered metallacycles. Self-assembly of the Pd(C,N,O) units gave place to the polynu- clear structure of 1a . Treatment of 1a with PPh 3 or PPh 2 CH 2 CH 2 PPh 2 in molar ratio Pd(II)/PPh 3 = 1/1 or Pd(II)/PPh 2 CH 2 CH 2 PPh 2 = 2/1 produced the mononuclear or dinuclear compound of schematic formula [Pd(C,N,O)(PPh 3 )] ( 2a ) or {[P d (C,N,O)] 2 ( μ2 -PPh 2 CH 2 CH 2 PPh 2 )} ( 3a ), respectively. Compounds a were char- acterized by elemental analysis, high resolution ESI-( + ) mass spectrometry, IR, and NMR. In addition, the crystal structure of the adducts 2a ·2(CH 2 Cl-CH 2 Cl) and 3a ·5(dmso) was determined by single crystal X- ray diffraction analysis. Most compounds a were noncytotoxic or poorly cytotoxic. Nonetheless, 2a was moderately cytotoxic against the MCF-7 breast and HCT-116 colon human cancer cell lines, and presented very low cytotoxicity towards normal skin human BJ cells. Compounds a showed moderate antibacterial activity against some Gram-positive ( B. subtilis and S. aureus ) and Gram-negative ( E. coli ) bacterial strains, and displayed also moderate antioxidant activity, producing 3a the best antioxidant activity. 1a changed the electrophoretic mobility of the pBluescript SK + plasmid DNA. This change followed the pattern of cisplatin , but it started at a concentration twenty times higher than with cisplatin . Moreover, compounds 1a - 3a inhibited topoisomerase IIα at concentrations of 10, 50 and 25 μM, respectively. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.jorganchem.2022.122555 | - |
dc.relation.ispartof | Journal of Organometallic Chemistry, 2022, vol. 983, p. 1-11 | - |
dc.relation.uri | https://doi.org/10.1016/j.jorganchem.2022.122555 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject.classification | Pal·ladi (Element químic) | - |
dc.subject.classification | Antioxidants | - |
dc.subject.classification | ADN | - |
dc.subject.other | Palladium | - |
dc.subject.other | Antioxidants | - |
dc.subject.other | DNA | - |
dc.title | Synthesis and biological properties of palladium(II) cyclometallated compounds derived from ( E )-2-((4-hydroxybenzylidene)amino)phenol | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 726996 | - |
dc.date.updated | 2024-08-02T10:49:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
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File | Description | Size | Format | |
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254027.pdf | 1.65 MB | Adobe PDF | View/Open |
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