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https://hdl.handle.net/2445/214867
Title: | Preguntas PICO y metodología DELPHI para mejorar el manejo de los pacientes con porfiria hepática aguda |
Author: | Riera Mestre, Antoni García Morillo, José Salvador Castelbón Fernández, Javier Hernández Contreras, María Encarnación Aguilera, Paula Jacob, Javier Martínez Valle, Fernando Guillén Navarro, Encarna Morales Conejo, Montserrat |
Keywords: | Porfíria Malalties del fetge Porphyria Liver diseases |
Issue Date: | 1-May-2024 |
Publisher: | Elsevier BV |
Abstract: | Background: Acute hepatic porphyrias (AHPs) are a group of rare diseases that encompasses acute intermittent porphyria, variegate porphyria, hereditary coproporphyria, and 5-aminolaevulinic acid dehydratase deficiency porphyria. Symptoms of AHP are nonspecific which, together with its low prevalence, difficult the diagnosis and follow-up of these patients. Material and methods: This project used DELPHI methodology to answer PICO questions related to management of patients with AHPs. The objective was to reach a consensus among multidisciplinary porhyria experts providing answers to those PICO questions for improving diagnosis and follow-up of patients with AHP. Results: Ten PICO questions were defined and grouped in four domains: 1. Biochemical diagnosis of patients with AHP. 2. Molecular tests for patients with AHP. 3. Follow-up of patients with AHP. 4. Screening for long-term complications of patients with AHP. Conclusions: PICO questions and DELPHI methodology have provided a consensus on relevant and controversial issues for improving the management of patients with AHP. (c) 2024 The Authors. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.rce.2024.04.003 |
It is part of: | Revista Clínica Española, 2024, vol. 224, num. 5, p. 272-280 |
URI: | https://hdl.handle.net/2445/214867 |
Related resource: | https://doi.org/10.1016/j.rce.2024.04.003 |
ISSN: | 1578-1860 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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