Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/214976
Title: | Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. |
Author: | Bosch, Marta Sánchez Álvarez, Miguel Fajardo, Alba Kapetanovic, Ronan Steiner, Bernhard Dutra, Filipe Moreira, Luciana López, Juan Antonio Campo, Rocío Marí, Montserrat Morales Paytuvi, Frederic Tort, Olivia Gubern, Albert Templin, Rachel M. Curson, James E. B. Martel, Nick Català, Cristina Lozano, Francisco Tebar Ramon, Francesc Enrich Bastús, Carles Vázquez, Jesús Del Pozo, Miguel Angel Sweet, Matthew J. Bozza, Patricia T. Gross, Steven P. Parton, Robert G. Pol i Sorolla, Albert |
Keywords: | Teixit adipós Immunologia Bacteris Metabolisme cel·lular Adipose tissues Immunology Bacteria Cell metabolism |
Issue Date: | 16-Oct-2020 |
Publisher: | American Association for the Advancement of Science |
Abstract: | Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1126/science.aay8085 |
It is part of: | Science, 2020, vol. 370, num.6514 |
URI: | http://hdl.handle.net/2445/214976 |
Related resource: | https://doi.org/10.1126/science.aay8085 |
ISSN: | 0036-8075 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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231452.pdf | 12.64 MB | Adobe PDF | View/Open |
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