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http://hdl.handle.net/2445/215142
Title: | 1,3,5-Triazine as branching connector for the construction of novel antimicrobial peptide dendrimers: synthesis and biological characterization |
Author: | Sheyi, Rotimi Mhlongo, Jessica T. Jorba, Marta Fusté i Domínguez, Ester Sharma, Anamika Viñas, Miquel Albericio Palomera, Fernando Espinal, Paula de la Torre, Beatriz G. |
Keywords: | Medicaments antibacterians Dendrímers Pèptids Antibacterial agents Dendrimers Peptides |
Issue Date: | 28-May-2024 |
Publisher: | MDPI |
Abstract: | Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and development displaying broad biological activity. Triazine-based dendrimers were fully synthesized in the solid phase, and their antimicrobial activity and some insights into their mechanisms of action were explored. Triazine is present in a large number of compounds with highly diverse biological targets with broad biological activities and could be an excellent branching unit to accommodate peptides. Our results show that the novel peptide dendrimers synthesized have remarkable antimicrobial activity against Gram-negative bacteria (E. coli and P. aeruginosa) and suggest that they may be useful in neutralizing the effect of efflux machinery on resistance. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms25115883 |
It is part of: | International Journal of Molecular Sciences, 2024, vol. 25, num.11 |
URI: | http://hdl.handle.net/2445/215142 |
Related resource: | https://doi.org/10.3390/ijms25115883 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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