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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215662
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dc.contributor.authorGomila, Alexandre MJ-
dc.contributor.authorRustler, Karin-
dc.contributor.authorMaleeva, Galyna-
dc.contributor.authorNin-Hill, Alba-
dc.contributor.authorWutz, Daniel-
dc.contributor.authorBautista-Barrufet, Antoni-
dc.contributor.authorRovira, Xavier-
dc.contributor.authorBosch, Miquel-
dc.contributor.authorMukhametova, Elvira-
dc.contributor.authorPetukhova, Elena-
dc.contributor.authorPonomareva, Daria-
dc.contributor.authorMukhamedyarov, Marat-
dc.contributor.authorPeiretti, Franck-
dc.contributor.authorAlfonso Prieto, Mercedes-
dc.contributor.authorRovira i Virgili, Carme-
dc.contributor.authorKönig, Burkhard-
dc.contributor.authorBregestovski, Piotr-
dc.contributor.authorGorostiza, Pau-
dc.date.accessioned2024-10-10T14:14:28Z-
dc.date.available2024-10-10T14:14:28Z-
dc.date.issued2020-11-19-
dc.identifier.issn2451-9456-
dc.identifier.urihttps://hdl.handle.net/2445/215662-
dc.description.abstractGlycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier Inc.-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.chembiol.2020.08.005-
dc.relation.ispartofCell Chemical Biology, 2020, vol. 27, p. 1425-1433-
dc.relation.urihttps://doi.org/10.1016/j.chembiol.2020.08.005-
dc.rightscc-by-nc-nd (c) Gomila, Alexandre MJ, et al., 2020-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationFotoquímica-
dc.subject.classificationFotofarmacologia-
dc.subject.otherPhotochemistry-
dc.subject.otherPhotopharmacology-
dc.titlePhotocontrol of endogenous glycine receptors in vivo-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec744515-
dc.date.updated2024-10-10T14:14:28Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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