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Título: | Proximity-induced pharmacology for amyloid-related diseases<br /> |
Autor: | Bertran-Mostazo, Andrea Putriute, Gabrielé Álvarez-Berbel, Irene Busquets i Viñas, Ma. Antonia Galdeano Cantador, Carlos Espargaró Colomé, Alba Sabaté Lagunas, Raimon |
Materia: | Malalties neurodegeneratives Amiloïdosi Disseny de medicaments Neurodegenerative Diseases Amyloidosis Drug design |
Fecha de publicación: | 4-mar-2024 |
Publicado por: | MDPI |
Resumen: | <p>Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge</p><p>approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing</p><p>small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects</p><p>that can break down pathogenic proteins and reduce the buildup of plaques. One of the most</p><p>promising aspects of this drug discovery modality is that it can be used to target specific types of</p><p>amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s</p><p>disease. This level of specificity could allow for more targeted and effective treatments. With ongoing</p><p>research and development, it is hoped that these treatments can be refined and optimized to provide</p><p>even greater benefits to patients. As our understanding of the underlying mechanisms of these</p><p>diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly</p><p>important tool in the fight against dementia and other related conditions.</p> |
Nota: | Reproducció del document publicat a: https://doi.org/10.3390/cells13050449 |
Es parte de: | Cells, 2024, vol. 13 |
URI: | https://hdl.handle.net/2445/215920 |
Recurso relacionado: | https://doi.org/10.3390/cells13050449 |
ISSN: | 2073-4409 |
Aparece en las colecciones: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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