Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215920
Title: Proximity-induced pharmacology for amyloid-related diseases<br />
Author: Bertran-Mostazo, Andrea
Putriute, Gabrielé
Álvarez-Berbel, Irene
Busquets i Viñas, Ma. Antonia
Galdeano Cantador, Carlos
Espargaró Colomé, Alba
Sabaté Lagunas, Raimon
Keywords: Malalties neurodegeneratives
Amiloïdosi
Disseny de medicaments
Neurodegenerative Diseases
Amyloidosis
Drug design
Issue Date: 4-Mar-2024
Publisher: MDPI
Abstract: <p>Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge</p><p>approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing</p><p>small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects</p><p>that can break down pathogenic proteins and reduce the buildup of plaques. One of the most</p><p>promising aspects of this drug discovery modality is that it can be used to target specific types of</p><p>amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s</p><p>disease. This level of specificity could allow for more targeted and effective treatments. With ongoing</p><p>research and development, it is hoped that these treatments can be refined and optimized to provide</p><p>even greater benefits to patients. As our understanding of the underlying mechanisms of these</p><p>diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly</p><p>important tool in the fight against dementia and other related conditions.</p>
Note: Reproducció del document publicat a: https://doi.org/10.3390/cells13050449
It is part of: Cells, 2024, vol. 13
URI: https://hdl.handle.net/2445/215920
Related resource: https://doi.org/10.3390/cells13050449
ISSN: 2073-4409
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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