Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216275
Title: Etiological analysis of discarded measles in the context of a measles outbreak among a highly immunized population
Author: Sowers, Sun
Torner Gràcia, Núria
Mercader i Verdés, Sara
Domínguez García, Àngela
Martínez Rodríguez, Ana
Costa, Josep
Abernathyc, S. Emily
Bellinic, William. J.
Hickmanc, Carol. J.
Keywords: Exantema
Diagnòstic diferencial
Xarampió
Exanthemata
Differential diagnosis
Measles
Issue Date: 29-Nov-2022
Publisher: Wiley
Abstract: Background: Measles can lead to serious complications and remains an important cause of morbidity and mortality worldwide. In this study we aimed to assess the etiological diagnosis of discarded measles cases in the context of an outbreak among a highly immunized population. Methods: We conducted a retrospective observational study of discarded measles cases from an outbreak that occurred from October 2006 to July 2007 in Catalonia. A confirmed case was defined as having a positive measles serum IgM result and/or a positive result by RT-PCR in urine and/or nasopharyngeal swab; or an epidemiological link to a confirmed case. Serum specimens were tested by a commercially available indirect-format and by an in-house capture-format measles IgM enzyme immunoassays. Results: Testing of 89 samples discarded for measles determined the etiologies for 10 (11.2%), including one rubella, three human herpes virus 6, and six measles infections. Of 381 confirmed cases in the outbreak, 10% had received at least one dose of the measles-mumps-rubella vaccine versus 54% of the discarded for measles (OR: 0.09; 95% CI: 0.06, 0.14; p < 0.001). Conclusions: Highly sensitive surveillance systems are critical to identifying cases, responding to outbreaks and verifying progress towards measles elimination. Molecular tools for measles detection and differential diagnosis, and collection of appropriate specimens for molecular and serological testing are essential to correctly diagnose suspected measles infection.
Note: Reproducció del document publicat a: https://doi.org/10.1111/ped.15430
It is part of: Pediatrics International, 2022, vol. 65, num.1, p. e15430
URI: https://hdl.handle.net/2445/216275
Related resource: https://doi.org/10.1111/ped.15430
ISSN: 1328-8067
Appears in Collections:Articles publicats en revistes (Medicina)

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