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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216956
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dc.contributor.authorMitjans Niubó, Marina-
dc.contributor.authorPapiol, Sergi-
dc.contributor.authorFatjó-Vilas Mestre, Mar-
dc.contributor.authorGonzález-Peñas, Javier-
dc.contributor.authorAcosta-Díez, Miriam-
dc.contributor.authorZafrilla-López, Marina -
dc.contributor.authorCostas, Javier-
dc.contributor.authorArango López, Celso-
dc.contributor.authorVilella, Elisabet-
dc.contributor.authorMartorell, Lourdes-
dc.contributor.authorMoltó, M. Dolors-
dc.contributor.authorBobes García, Julio-
dc.contributor.authorCrespo-Facorro, Benedicto-
dc.contributor.authorGonzález-Pinto, Ana-
dc.contributor.authorFañanás Saura, Lourdes-
dc.contributor.authorRosa de la Cruz, Araceli-
dc.contributor.authorArias Sampériz, Bárbara-
dc.date.accessioned2024-12-05T15:50:05Z-
dc.date.available2024-12-05T15:50:05Z-
dc.date.issued2024-09-01-
dc.identifier.issn0924-977X-
dc.identifier.urihttps://hdl.handle.net/2445/216956-
dc.description.abstractEvidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.   -
dc.format.extent6 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2024.04.017-
dc.relation.ispartofEuropean Neuropsychopharmacology, 2024, vol. 86, p. 49-54-
dc.relation.urihttps://doi.org/10.1016/j.euroneuro.2024.04.017-
dc.rightscc-by-nc-nd (c) Mitjans Niubó, Marina et al., 2024-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceArticles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)-
dc.subject.classificationEsquizofrènia-
dc.subject.classificationTrastorn bipolar-
dc.subject.classificationDepressió psíquica-
dc.subject.classificationDiferències entre sexes (Psicologia)-
dc.subject.otherSchizophrenia-
dc.subject.otherManic-depressive illness-
dc.subject.otherMental depression-
dc.subject.otherSex differences (Psychology)-
dc.titleShared vulnerability and sex-dependent polygenic burden in psychotic disorders-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec750527-
dc.date.updated2024-12-05T15:50:05Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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