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https://hdl.handle.net/2445/216990Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Menéndez Buján, Pablo | - |
| dc.contributor.advisor | Sánchez Martínez, Diego | - |
| dc.contributor.author | Tirado Cabrera, Néstor | - |
| dc.contributor.other | Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut | - |
| dc.date.accessioned | 2024-12-10T10:05:38Z | - |
| dc.date.available | 2024-12-10T10:05:38Z | - |
| dc.date.issued | 2024-09-20 | - |
| dc.identifier.uri | https://hdl.handle.net/2445/216990 | - |
| dc.description.abstract | [eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR. | ca |
| dc.format.extent | 176 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | ca |
| dc.publisher | Universitat de Barcelona | - |
| dc.rights | cc by-nc-sa (c) Tirado Cabrera, Néstor, 2024 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | * |
| dc.source | Tesis Doctorals - Facultat - Medicina i Ciències de la Salut | - |
| dc.subject.classification | Immunologia | - |
| dc.subject.classification | Immunoteràpia | - |
| dc.subject.classification | Hematologia | - |
| dc.subject.classification | Leucèmia aguda | - |
| dc.subject.other | Immunology | - |
| dc.subject.other | Immunotheraphy | - |
| dc.subject.other | Hematology | - |
| dc.subject.other | Acute leukemia | - |
| dc.title | New immunotherapeutic strategies in acute leukemia | ca |
| dc.type | info:eu-repo/semantics/doctoralThesis | ca |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
| dc.identifier.tdx | http://hdl.handle.net/10803/692700 | - |
| Appears in Collections: | Tesis Doctorals - Facultat - Medicina i Ciències de la Salut | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| NTC_PhD_THESIS.pdf | 89.77 MB | Adobe PDF | View/Open |
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