Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/217998
Title: A Novel Approach for Dermal Application of Pranoprofen-Loaded Lipid Nanoparticles for the Treatment of Post-Tattoo Inflammatory Reactions
Author: De Grau, Guillermo
Mallandrich Miret, Mireia
Sosa Díaz, Lilian Elisa
Espinoza, Lupe Carolina
Calpena Campmany, Ana Cristina
Bozal de Febrer, Núria
Rodríguez Allué, Manuel José
Garduño Ramírez, María Luisa del Carmen
Rincón, María
Keywords: Malalties de la pell
Lípids
Nanopartícules
Tatuatges
Skin diseases
Lipids
Nanoparticles
Tattooing
Issue Date: May-2024
Publisher: MDPI
Abstract: Recently, the number of people acquiring tattoos has increased, with tattoos gaining significant popularity in people between 20 and 40 years old. Inflammation is a common reaction associated with tattooing. The purpose of this study was to evaluate a nanostructured lipid carrier loading pranoprofen (PRA-NLC) as a tattoo aftercare formulation to reduce the inflammation associated with tattooing. In this context, the in vitro drug release and the ex vivo permeation-through-human-skin tests using Franz cells were appraised. The tolerance of our formulation on the skin was evaluated by studying the skin’s biomechanical properties. In addition, an in vivo anti-inflammatory study was conducted on mice skin to evaluate the efficacy of the formulation applied topically after tattooing the animals. PRA-NLC showed a sustained release up to 72 h, and the amount of pranoprofen retained in the skin was found to be 33.48 µg/g/cm2. The formulation proved to be well tolerated; it increased stratum corneum hydration, and no signs of skin irritation were observed. Furthermore, it was demonstrated to be non-cytotoxic since the cell viability was greater than 80%. Based on these results, we concluded that PRA-NLC represents a suitable drug delivery carrier for the transdermal delivery of pranoprofen to alleviate the local skin inflammation associated with tattooing.
Note: Reproducció del document publicat a: https://doi.org/https://doi.org/10.3390/pharmaceutics16050643
It is part of: Pharmaceutics, 2024, vol. 16, num.5, p. 643
URI: https://hdl.handle.net/2445/217998
Related resource: https://doi.org/https://doi.org/10.3390/pharmaceutics16050643
ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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