Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218237
Title: Age of language acquisition influences the cortical language organization in multilingual patients undergoing awake brain mapping
Author: Fernández Coello, Alejandro
Havas, Viktória
Juncadella i Puig, Montserrat
Sierpowska, Joanna
Rodríguez Fornells, Antoni
Gabarrós, Andreu
Keywords: Tumors cerebrals
Escorça cerebral
Adults
Mapatge del cervell
Estimulació del cervell
Brain tumors
Cerebral cortex
Adulthood
Brain mapping
Brain stimulation
Issue Date: 1-Jun-2016
Publisher: American Association of Neurological Surgeons
Abstract: Objective: Most knowledge regarding the anatomical organization of multilingualism is based on aphasiology and functional imaging studies. However, the results have still to be validated by the gold standard approach, namely electrical stimulation mapping (ESM) during awake neurosurgical procedures. In this ESM study the authors describe language representation in a highly specific group of 13 multilingual individuals, focusing on how age of acquisition may influence the cortical organization of language. Methods: Thirteen patients who had a high degree of proficiency in multiple languages and were harboring lesions within the dominant, left hemisphere underwent ESM while being operated on under awake conditions. Demographic and language data were recorded in relation to age of language acquisition (for native languages and early- and late-acquired languages), neuropsychological pre- and postoperative language testing, the number and location of language sites, and overlapping distribution in terms of language acquisition time. Lesion growth patterns and histopathological characteristics, location, and size were also recorded. The distribution of language sites was analyzed with respect to age of acquisition and overlap. Results: The functional language-related sites were distributed in the frontal (55%), temporal (29%), and parietal lobes (16%). The total number of native language sites was 47. Early-acquired languages (including native languages) were represented in 97 sites (55 overlapped) and late-acquired languages in 70 sites (45 overlapped). The overlapping distribution was 20% for early-early, 71% for early-late, and 9% for late-late. The average lesion size (maximum diameter) was 3.3 cm. There were 5 fast-growing and 7 slow-growing lesions. Conclusions: Cortical language distribution in multilingual patients is not homogeneous, and it is influenced by age of acquisition. Early-acquired languages have a greater cortical representation than languages acquired later. The prevalent native and early-acquired languages are largely represented within the perisylvian left hemisphere frontoparietotemporal areas, and the less prevalent late-acquired languages are mostly overlapped with them.
Note: Reproducció del document publicat a: https://doi.org/10.3171/2016.5.JNS152791
It is part of: Journal of Neurosurgery, 2016, vol. 126, num.6, p. 1912-1923
URI: https://hdl.handle.net/2445/218237
Related resource: https://doi.org/10.3171/2016.5.JNS152791
ISSN: 0022-3085
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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