Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/218527| Title: | Backtracking NOM1::ETV6 fusion to neonatal pathogenesis of t(7;12) (q36;p13) infant AML. |
| Author: | Bousquets Muñoz, Pablo Molina, Òscar Varela, Ignacio Álvarez-Eguiluz, Ángel Fernández-Mateos, Javier Gómez, Ana Sánchez, Elena G. Balbín, Milagros Ruano, David Ramírez-Orellana, Manuel Puente, Xose S. Menéndez, Pablo Velasco-Hernandez, Talia |
| Keywords: | Leucèmia mieloide Cromosomes humans Infants Myeloid leukemia Human chromosomes Children |
| Issue Date: | 17-May-2024 |
| Publisher: | Springer Nature |
| Abstract: | This work demonstrated the prenatal origin of the translocation t(7;12) giving rise to the ETV6-NOM1 fusion protein, in a 5-month-old patient with acute myeloblastic leukemia using an umbilical cord blood (CB) sample from the patient stored at birth. Our findings revealed the presence of a specific t(7;12)/ETV6-NOM1 fusion in both CD34+ hematopoietic stem/progenitor cells and in the CD34-CD33+ myeloid cellular compartment isolated from the patient’s umbilical CB. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41375-024-02293-9 |
| It is part of: | Leukemia, 2024, vol. 38, p. 1808-1812 |
| URI: | https://hdl.handle.net/2445/218527 |
| Related resource: | https://doi.org/10.1038/s41375-024-02293-9 |
| ISSN: | 0887-6924 |
| Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 873634.pdf | 9.56 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License
