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https://hdl.handle.net/2445/219067| Title: | Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy |
| Author: | Domingo, Pere (Domingo Pedrol) Giralt i Oms, Marta Gavaldà i Navarro, Aleix Blasco Roset, Albert Delgado Anglés, Alejandro Gallego Escuredo, José Miguel Gutiérrez, Maria del Mar Mateo, Maria Gracia Cereijo Téllez, Rubén Domingo i Pedrol, Joan Carles Villarroya i Gombau, Francesc Villarroya i Terrade, Joan |
| Keywords: | Síndrome de lipodistròfia associada a VIH Inflamació Autofàgia Teixit adipós HIV-associated lipodystrophy syndrome Inflammation Autophagy Adipose tissues |
| Issue Date: | 1-Dec-2022 |
| Publisher: | Taylor & Francis |
| Abstract: | Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 year-old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that aging of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1080/21623945.2022.2042962 |
| It is part of: | Adipocyte, 2022, vol. 11, num.1, p. 143-152 |
| URI: | https://hdl.handle.net/2445/219067 |
| Related resource: | https://doi.org/10.1080/21623945.2022.2042962 |
| ISSN: | 2162-3945 |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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