Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219503
Title: Serological Outcome in the First Months of Life of Children Born to Mothers with SARS-CoV-2 Infection during Pregnancy
Author: Pons Tomàs, Gemma
Martínez de Albéniz, Irene
Ríos Barnés, María
Gamell, Anna
Simó Nebot, Sílvia
Balsells Mejía, Sol
Hernández García, María
Melé Casas, Maria
Sánchez, Emilia
Monsonís, Manuel
Gené, Amadeu
López, Marta
Salvia-Roiges, Ma Dolors
Garcia García, Juan José
Fortuny Guasch, Claudia
Fumadó, Victoria
Keywords: SARS-CoV-2
Embaràs
Infants nadons
Autoanticossos
SARS-CoV-2
Pregnancy
Newborn infants
Autoantibodies
Issue Date: 6-Sep-2024
Publisher: MDPI
Abstract: Background: The objective of this study is to analyze the transplacental transmission of SARS-CoV-2 antibodies, their persistence in newborns, the factors that may influence this transmission, and the protection these antibodies confer over time. Methods: This prospective cohort was conducted in a tertiary pediatric hospital in the Barcelona Metropolitan Region, Spain. It included neonates born to mothers who had SARS-CoV-2 infection during pregnancy or delivery between August 2020 and January 2022. We followed the recruited children for at least six months, and blood tests were performed to determine the presence of SARS-CoV-2 antibodies. Results: A total of 101 children were recruited. Among the serologies performed on children under three months of age, 44/82 were positive (53.7%). Newborns whose mothers presented more severe disease exhibited higher seropositivity odds (coefficient 9.747; p = 0.002). There were increased preterm deliveries when maternal infection occurred closer to the time of delivery. No severe SARS-CoV-2 infections were detected in children during the follow-up. Conclusions: Slightly more than half of the SARS-CoV-2 serologies performed in the first three months were positive. This appears to confer protection during early childhood. The severity of maternal infection is the most significant factor influencing the transmission of antibodies in children born to unvaccinated mothers.
Note: Reproducció del document publicat a: https://doi.org/10.3390/children11091095
It is part of: Children, 2024, vol. 11, num.9, p. 1095
URI: https://hdl.handle.net/2445/219503
Related resource: https://doi.org/10.3390/children11091095
ISSN: 2227-9067
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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