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https://hdl.handle.net/2445/220233| Title: | Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder |
| Author: | Iranzo, Alex Mammana, Angela Muñoz Lopetegi, Amaia Dellavalle, Sofia Mayà Casalprim, Gerard Rossi, Marcello Serradell, Mónica Baiardi, Simone Arqueros, Aurora Quadalti, Corinne Perissinotti, Andrés Ruggeri, Edoardo Santamaria Cano, Joan Gaig Ventura, Carles Parchi, Piero |
| Keywords: | Trastorns del son Demència amb cossos de Lewy Malaltia de Parkinson Sleep disorders Lewy body dementia Parkinson's disease |
| Issue Date: | 2-May-2023 |
| Publisher: | Lippincott, Williams & Wilkins. Wolters Kluwer Health |
| Abstract: | Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1212/WNL.0000000000207147 |
| It is part of: | Neurology, 2023, vol. 100, num.18, p. E1944-E1954 |
| URI: | https://hdl.handle.net/2445/220233 |
| Related resource: | https://doi.org/10.1212/WNL.0000000000207147 |
| ISSN: | 0028-3878 |
| Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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| 884639.pdf | 454.93 kB | Adobe PDF | View/Open |
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